Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.72 |
| ▸ | GAA | P10253 | 6/20 | 0.72 |
| ▸ | CA2 | P00918 | 2/20 | 0.71 |
| ▸ | STS | P08842 | 2/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | ALPL | P05186 | 3/20 | 0.60 |
| ▸ | ALPI | P09923 | 3/20 | 0.60 |
| ▸ | GLA | P06280 | 5/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA5A | P35218 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1358175 | 0.89 | STS (0.71) | KDM4EALDH1A1GAACA2STS | |
| SCHEMBL38662608 | 0.86 | ALDH1A1 (0.76) | KDM4EALDH1A1GAACA2STS | |
| SCHEMBL10850187 | 0.84 | KDM4E (1.00) | KDM4EALDH1A1GAACA2STS | |
| SCHEMBL30228363 | 0.84 | ALDH1A1 (0.52) | KDM4EALDH1A1GAACA2STS | |
| SCHEMBL17179699 | 0.83 | AGER (0.63) | KDM4EALDH1A1GAAHSD17B10HPGD | |
| SCHEMBL30139608 | 0.83 | ALDH1A1 (0.76) | KDM4EALDH1A1GAACA2STS | |
| SCHEMBL25184 | 0.83 | ALDH1A1 (0.76) | KDM4EALDH1A1GAACA2STS | |
| SCHEMBL9451464 | 0.83 | STS (1.00) | KDM4EALDH1A1GAACA2STS | |
| Hydrogen Sulfide SCHEMBL6879015 | 0.83 | KDM4E (0.55) | KDM4EALDH1A1GAACA2STS | |
| SCHEMBL3761326 | 0.82 | ALDH1A1 (0.74) | KDM4EALDH1A1GAACA2STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240327393-A1 | FERROPTOSIS MODULATORS, PREPARATIONS, AND USES THEREOF | Sironax Ltd. (KY) | 2024-10-03 | — | — | US | disclosed |
| EP-4367111-A1 | FERROPTOSIS MODULATORS, PREPARATIONS, AND USES THEREOF | Sironax Ltd. (KY) | 2024-05-15 | — | — | EP | disclosed |
| CN-117999259-A | Iron death modulators, their preparation and use | 维泰瑞隆有限公司 | 2024-05-07 | — | — | CN | disclosed |
| US-20240052169-A1 | Deuterated Fluorophores | HOWARD HUGHES MEDICAL INSTITUTE (US) | 2024-02-15 | — | — | US | disclosed |
| US-11787946-B2 | Deuterated fluorophores | HOWARD HUGHES MEDICAL INSTITUTE (US) | 2023-10-17 | — | — | US | disclosed |
| CN-112010844-B | Preparation method and application of N- (pyrimidine-2-yl) coumarin-7-amine derivative as protein kinase inhibitor | 中国药科大学 | 2023-07-25 | — | — | CN | disclosed |
| WO-2023280296-A1 | FERROPTOSIS MODULATORS, PREPARATIONS, AND USES THEREOF | Sironax Ltd. (KY) | 2023-01-12 | — | — | WO | disclosed |
| US-20210347994-A1 | DEUTERATED FLUOROPHORES | HOWARD HUGHES MEDICAL INSTITUTE (US) | 2021-11-11 | — | — | US | disclosed |
| US-11091643-B2 | Deuterated fluorophores | HOWARD HUGHES MEDICAL INSTITUTE (US) | 2021-08-17 | — | — | US | disclosed |
| EP-3801495-A1 | DEUTERATED FLUOROPHORES | Howard Hughes Medical Institute (US) | 2021-04-14 | — | — | EP | disclosed |
| WO-2015156264-A1 | NOVEL GLUCOSE DERIVATIVE, AND CELL IMAGING METHOD AND IMAGING AGENT USING SAID DERIVATIVE | 国立大学法人弘前大学 | 2015-10-15 | — | — | WO | disclosed |
| US-8067619-B2 | Coumarin derivatives as ion channel openers | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-11-29 | — | — | US | disclosed |
| US-20100069474-A1 | NOVEL COUMARIN DERIVATIVES AS ION CHANNEL OPENERS | JAIN NARESHKUMAR F | 2010-03-18 | — | — | US | disclosed |
| US-7662975-B2 | trifluoro-methanesulfonic acid 3-(2,4-dimethoxy-phenyl)-4-(2-methoxy-ethyl)-2-oxo-2H-chromen-7-yl ester as potassium channel modulators; urinary incontinence, overactive bladder, hypertension, erectile dysfunction, female sexual disorders, dysmenorrhea, irritable bowl syndrome, airway hyperactivity | JANSSEN PHARMACEUTICA, NV (BE) | 2010-02-16 | — | — | US | disclosed |
| US-20080194522-A1 | Development of Fluorogenic Substrates For Monoamine Oxidases (Mao-A and Mao-B) | TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE | 2008-08-14 | — | — | US | disclosed |
| US-20080194522-A1 | Development of Fluorogenic Substrates For Monoamine Oxidases (Mao-A and Mao-B) | TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE | 2008-08-14 | — | — | US | disclosed |
| US-20080194522-A1 | Development of Fluorogenic Substrates For Monoamine Oxidases (Mao-A and Mao-B) | TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE | 2008-08-14 | — | — | US | disclosed |
| EP-1846386-A2 | NOVEL COUMARIN DERIVATIVES AS ION CHANNEL OPENERS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-24 | — | — | EP | disclosed |
| US-20070037877-A1 | trifluoro-methanesulfonic acid 3-(2,4-dimethoxy-phenyl)-4-(2-methoxy-ethyl)-2-oxo-2H-chromen-7-yl ester as potassium channel modulators; urinary incontinence, overactive bladder, hypertension, erectile dysfunction, female sexual disorders, dysmenorrhea, irritable bowl syndrome, airway hyperactivity | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-02-15 | — | — | US | disclosed |
| WO-2006078833-A2 | NOVEL COUMARIN DERIVATIVES AS ION CHANNEL OPENERS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240052169-A1 | Deuterated Fluorophores | HDHD5, DRD4, ARF4 | KDM4E 1330/4885ALDH1A1 836/4885GAA 1327/4885 |
| US-20080194522-A1 | Development of Fluorogenic Substrates For Monoamine Oxidases (Mao-A and Mao-B) | MAOA, MAOB, COMT | KDM4E 1183/4885ALDH1A1 181/4885GAA 67/4885 |
| US-20210347994-A1 | DEUTERATED FLUOROPHORES | HDHD5, DRD4, ARF4 | KDM4E 1330/4885ALDH1A1 836/4885GAA 1327/4885 |
| US-20240327393-A1 | FERROPTOSIS MODULATORS, PREPARATIONS, AND USES THEREOF | AIFM2, GPX1, GPX4 | KDM4E 3854/4885ALDH1A1 1306/4885GAA 861/4885 |
| US-20100069474-A1 | NOVEL COUMARIN DERIVATIVES AS ION CHANNEL OPENERS | KCNJ2, KCNN3, KCNN2 | KDM4E 3289/4885ALDH1A1 1678/4885GAA 2313/4885 |
| US-20070037877-A1 | trifluoro-methanesulfonic acid 3-(2,4-dimethoxy-phenyl)-4-(2-methoxy-ethyl)-2-oxo-2H-chromen-7-yl ester as potassium channel modulators; urinary incontinence, overactive bladder, hypertension, erectile dysfunction, female sexual disorders, dysmenorrhea, irritable bowl syndrome, airway hyperactivity | KCNN2, KCNH3, KCNN1 | KDM4E 756/4885ALDH1A1 1703/4885GAA 3285/4885 |
| US-11091643-B2 | Deuterated fluorophores | HDHD5, DRD4, ARF4 | KDM4E 1330/4885ALDH1A1 836/4885GAA 1327/4885 |
| US-11787946-B2 | Deuterated fluorophores | HDHD5, DRD4, ARF4 | KDM4E 1330/4885ALDH1A1 836/4885GAA 1327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.