SCHEMBL25185060

SCHEMBL25185060

COc1ccc(/C=C/C(=O)c2ccc(O)cc2O)cc1COc1cccc(C)c1C

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 5/20 0.66
▸ L3MBTL1 Q9Y468 1/20 0.66
▸ CYP19A1 P11511 1/20 0.63
▸ MEN1 O00255 6/20 0.62
▸ KMT2A Q03164 6/20 0.62
▸ ALDH1A1 P00352 5/20 0.62
▸ ABCG2 Q9UNQ0 4/20 0.62
▸ SMN1; SMN2 Q16637 3/20 0.62
▸ TDP1 Q9NUW8 2/20 0.62
▸ TP53 P04637 2/20 0.62
▸ CYP3A4 P08684 2/20 0.62
▸ HPGD P15428 2/20 0.62
▸ ALOX15 P16050 2/20 0.62
▸ MAPK1 P28482 2/20 0.62
▸ ALOX12 P18054 1/20 0.62
▸ RECQL P46063 1/20 0.59
▸ NFKB1 P19838 1/20 0.59
▸ NFKB2 Q00653 1/20 0.59
▸ RELA Q04206 1/20 0.59
▸ CTSL P07711 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25195119 0.92 RECQL (0.70) MAPTL3MBTL1CYP19A1MEN1KMT2A
SCHEMBL25190969 0.90 CYP19A1 (0.66) MAPTL3MBTL1CYP19A1MEN1KMT2A
SCHEMBL25201205 0.87 MAPT (0.72) MAPTL3MBTL1MEN1KMT2AALDH1A1
SCHEMBL30382969 0.87 MAPT (0.72) MAPTL3MBTL1MEN1KMT2AALDH1A1
SCHEMBL25279687 0.87 MAPT (0.72) MAPTL3MBTL1MEN1KMT2AALDH1A1
SCHEMBL25200457 0.86 CTSL (0.70) MAPTCYP19A1MEN1KMT2AALDH1A1
SCHEMBL25191450 0.86 CYP19A1 (0.66) MAPTCYP19A1MEN1KMT2AALDH1A1
SCHEMBL30383439 0.86 CTSL (0.70) MAPTCYP19A1MEN1KMT2AALDH1A1
SCHEMBL25279648 0.86 MEN1 (0.74) MAPTCYP19A1MEN1KMT2AALDH1A1
SCHEMBL25196256 0.86 CYP19A1 (0.62) MAPTL3MBTL1CYP19A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 — — US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 — — US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 — — WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 — — EP disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 — — US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B MAPT 3297/4885L3MBTL1 3658/4885CYP19A1 270/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 MAPT 3512/4885L3MBTL1 2560/4885CYP19A1 320/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 MAPT 3512/4885L3MBTL1 2560/4885CYP19A1 320/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback