SCHEMBL25188377

SCHEMBL25188377

NC1(O)C=CN([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C(=O)N1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CDA P32320 6/20 0.43
▸ SLC28A1 O00337 1/20 0.43
▸ SLC28A2 O43868 1/20 0.43
▸ SLC29A1 Q99808 1/20 0.43
▸ SLC28A3 Q9HAS3 1/20 0.43
▸ LMNA P02545 3/20 0.41
▸ MTOR P42345 2/20 0.41
▸ SMN1; SMN2 Q16637 2/20 0.41
▸ ALDH1A1 P00352 2/20 0.41
▸ THRB P10828 1/20 0.41
▸ MDM2 Q00987 1/20 0.41
▸ NCOA1 Q15788 1/20 0.41
▸ NCOA3 Q9Y6Q9 1/20 0.41
▸ POLB P06746 1/20 0.41
▸ GMNN O75496 1/20 0.41
▸ TP53 P04637 1/20 0.41
▸ NFKB1 P19838 1/20 0.41
▸ DNMT1 P26358 1/20 0.41
▸ THPO P40225 1/20 0.41
▸ HTT P42858 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3630509 0.88 LMNA (0.45) CDASLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL6906558 0.88 LMNA (0.45) CDASLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL10903345 0.86 CDA (0.42) CDASLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL31436719 0.86 CDA (0.42) CDASLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL27845966 0.84 CDA (0.41) CDASLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL17440122 0.84 CDA (0.41) CDASLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL29845228 0.84 CDA (0.41) CDASLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL22978939 0.84 CDA (0.41) CDASLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL4751008 0.84 LMNA (0.42) CDASLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL10903331 0.84 LMNA (0.42) CDASLC28A1SLC28A2SLC29A1SLC28A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024123207-A1 5'-О-(3-PHENYLPROPIONYL)-N4-HYDROXYCYTIDINE AND USE THEREOF федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации 2024-06-13 — — WO claimed
EP-4149252-A2 ENGINEERED GENE-EDITING PROTEINS Factor Bioscience Inc. (US) 2023-03-22 — — EP claimed
CN-113784721-B High activity compounds against COVID-19 阿堤亚制药公司 2025-06-13 — — CN disclosed
CN-116554249-B Antiviral compounds and uses thereof 北京恩泰伟医药科技有限公司 2025-03-18 — — CN disclosed
CN-119139338-A High activity compounds against COVID-19 阿堤亚制药公司 2024-12-17 — — CN disclosed
CN-119125384-A Method for determining concentration of Mo Nuola-pyrrosid and/or active metabolite beta-d-N4-hydroxycytosine in human body fluid based on liquid chromatography-mass spectrometry after chemical derivatization of benzoyl chloride 中国人民解放军海军军医大学第一附属医院 2024-12-13 — — CN disclosed
CN-118948877-A High activity compounds against COVID-19 阿堤亚制药公司 2024-11-15 — — CN disclosed
CN-118922430-A Preparation method of monabivalir and intermediate thereof 上海科胜药物研发药物有限公司 2024-11-08 — — CN disclosed
EP-4430055-A1 ESTER DERIVATIVES OF N4-HYDROXYCYTIDINE AND USE THEREOF Suzhou Spring-Sea Bio-Pharmaceuticals Co., Ltd. (CN) 2024-09-18 — — EP disclosed
EP-4430055-A1 ESTER DERIVATIVES OF N4-HYDROXYCYTIDINE AND USE THEREOF Suzhou Spring-Sea Bio-Pharmaceuticals Co., Ltd. (CN) 2024-09-18 — — EP disclosed
CN-118591377-A Antiviral prodrugs, intermediate and long acting formulations and methods 加利福尼亚大学董事会 2024-09-03 — — CN disclosed
WO-2023083295-A1 ESTER DERIVATIVES OF N4-HYDROXYCYTIDINE AND USE THEREOF SUZHOU SPRING-SEA BIO-PHARMACEUTICALS CO., LTD. (CN) 2023-05-19 — — WO disclosed
EP-4149252-A2 ENGINEERED GENE-EDITING PROTEINS Factor Bioscience Inc. (US) 2023-03-22 — — EP disclosed
CN-115768474-A Methods for treating COVID-19 related disorders 里格尔药品股份有限公司 2023-03-07 — — CN disclosed
CN-115666587-A N4-hydroxycytidine and derivatives and related antiviral uses thereof 埃默里大学 2023-01-31 — — CN disclosed
WO-2022262845-A1 ESTER DERIVATIVES OF N4-HYDROXYCYTIDINE AND USE THEREOF SUZHOU SPRING-SEA BIO-PHARMACEUTICALS CO., LTD. (CN) 2022-12-22 — — WO disclosed
WO-2022262845-A1 ESTER DERIVATIVES OF N4-HYDROXYCYTIDINE AND USE THEREOF SUZHOU SPRING-SEA BIO-PHARMACEUTICALS CO., LTD. (CN) 2022-12-22 — — WO disclosed
CN-108463103-B Targeted mutagenesis of tobacco berberine bridge enzyme-like nucleic acids 北卡罗来纳州立大学 2022-08-26 — — CN disclosed
CN-101862345-B Modified nucleosides for treatment of viral infections and abnormal cellular proliferation GILEAD SCIENCES INC 2014-06-04 — — CN disclosed
CN-101862345-A The modified nucleosides that is used for the treatment of viral infection and abnormal cell proliferation PHARMASSET LTD 2010-10-20 — — CN disclosed
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