SCHEMBL25190838

SCHEMBL25190838

O=C(O)CCOc1ccc(/C=C/C(=O)c2ccc(Br)cc2)cc1

nearest known ligand 0.70

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ MAOB P27338 6/20 0.70
▸ MAOA P21397 2/20 0.63
▸ CYP1B1 Q16678 1/20 0.58
▸ ABCG2 Q9UNQ0 4/20 0.57
▸ ESR1 P03372 1/20 0.57
▸ ESR2 Q92731 1/20 0.57
▸ BCHE P06276 2/20 0.55
▸ ACHE P22303 2/20 0.55
▸ NPC1 O15118 1/20 0.54
▸ MAPT P10636 1/20 0.54
▸ RAB9A P51151 1/20 0.54
▸ KMT2A Q03164 1/20 0.54
▸ HRH3 Q9Y5N1 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25218068 0.94 MAOB (0.68) MAOBMAOACYP1B1ABCG2ESR1
SCHEMBL25202277 0.88 MAPT (0.70) MAOBMAOACYP1B1ABCG2BCHE
SCHEMBL25208789 0.87 MAOB (0.70) MAOBMAOACYP1B1ABCG2BCHE
SCHEMBL25193934 0.87 MAOB (0.73) MAOBMAOACYP1B1ABCG2NPC1
SCHEMBL25188984 0.87 MAOB (0.71) MAOBMAOACYP1B1ABCG2BCHE
SCHEMBL25197151 0.87 MAOB (0.70) MAOBMAOACYP1B1ABCG2BCHE
SCHEMBL25184972 0.86 MAOB (0.73) MAOBMAOACYP1B1ABCG2ESR1
SCHEMBL25202033 0.86 MAOB (0.73) MAOBMAOACYP1B1ABCG2ESR1
SCHEMBL25185066 0.86 MAOB (0.73) MAOBMAOACYP1B1ABCG2ESR1
SCHEMBL25202224 0.86 MAOB (0.73) MAOBMAOACYP1B1ABCG2ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 — — US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 — — US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 — — WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 — — EP disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 — — US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B MAOB 1004/4885MAOA 1902/4885CYP1B1 230/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 MAOB 2435/4885MAOA 3145/4885CYP1B1 1027/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 MAOB 2435/4885MAOA 3145/4885CYP1B1 1027/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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