Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 11/20 | 0.41 |
| ▸ | USP2 | O75604 | 10/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.40 |
| ▸ | TP53 | P04637 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8992002 | 0.76 | CHRNA7 (0.37) | TSHR | |
| SCHEMBL2074309 | 0.74 | TSHR (0.39) | TSHRCYP2D6USP2ALDH1A1CYP2C19 | |
| SCHEMBL3714891 | 0.67 | KDM4E (0.34) | ALDH1A1 | |
| SCHEMBL28754378 | 0.66 | USP2 (0.41) | TSHRCYP2D6USP2CYP1A2ALDH1A1 | |
| SCHEMBL2519264 | 0.64 | HTR2C (0.33) | HTR2CHTR2B | |
| SCHEMBL8118171 | 0.63 | OPRM1 (0.47) | HPGDSMN1; SMN2MEN1KMT2AHTR2C | |
| SCHEMBL24582286 | 0.63 | TSHR (0.49) | TSHRCYP2D6USP2CYP1A2CYP3A4 | |
| SCHEMBL19139673 | 0.62 | TSHR (1.00) | TSHRCYP2D6USP2CYP1A2CYP3A4 | |
| SCHEMBL31657074 | 0.62 | HTR2C (0.43) | TSHRHTR2CHTR2B | |
| SCHEMBL8157271 | 0.60 | HTR2A (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547679-A1 | 2,3 DIHYDRO-1H-INDEN-1-YL- 2,7-DIAZASPIRO [3.6]NONANE DERIVATIVES AND THEIR USE AS ANTAGONISTS OR INVERSE AGONISTS OF THE GHRELIN RECEPTOR | Pfizer Inc. (US) | 2013-01-23 | — | — | EP | claimed |
| WO-2011114271-A1 | 2,3 DIHYDRO-1H-INDEN-1-YL- 2,7-DIAZASPIRO [3.6] NONANE DERIVATIVES AND THEIR USE AS ANTAGONISTS OR INVERSE AGONISTS OF THE GHRELIN RECEPTOR | PFIZER INC. (US) | 2011-09-22 | — | — | WO | claimed |