Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2436751 | 0.69 | PRCP (0.39) | HTR2CHTR2B | |
| SCHEMBL5698322 | 0.68 | HTR2A (0.44) | HTR2CHTR2B | |
| SCHEMBL2519261 | 0.64 | TSHR (0.44) | HTR2CHTR2B | |
| SCHEMBL10352714 | 0.63 | HTR2A (0.38) | HTR2CHTR2B | |
| SCHEMBL15571073 | 0.62 | SIGMAR1 (0.42) | OPRM1OPRD1 | |
| SCHEMBL30790640 | 0.62 | HTR6 (0.33) | — | |
| SCHEMBL1074094 | 0.61 | HTR2A (0.35) | HTR2CHTR2B | |
| SCHEMBL7185808 | 0.61 | HTR2A (0.35) | — | |
| SCHEMBL28839778 | 0.61 | HTR2A (0.35) | — | |
| SCHEMBL7185802 | 0.61 | HTR2A (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547679-A1 | 2,3 DIHYDRO-1H-INDEN-1-YL- 2,7-DIAZASPIRO [3.6]NONANE DERIVATIVES AND THEIR USE AS ANTAGONISTS OR INVERSE AGONISTS OF THE GHRELIN RECEPTOR | Pfizer Inc. (US) | 2013-01-23 | — | — | EP | claimed |
| WO-2011114271-A1 | 2,3 DIHYDRO-1H-INDEN-1-YL- 2,7-DIAZASPIRO [3.6] NONANE DERIVATIVES AND THEIR USE AS ANTAGONISTS OR INVERSE AGONISTS OF THE GHRELIN RECEPTOR | PFIZER INC. (US) | 2011-09-22 | — | — | WO | claimed |