Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 2/20 | 0.65 |
| ▸ | FEN1 | P39748 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | CES2 | O00748 | 1/20 | 0.54 |
| ▸ | CES1 | P23141 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29987169 | 0.87 | ERCC5 (0.74) | ERCC5FEN1RAB9AMEN1KMT2A | |
| SCHEMBL4024952 | 0.82 | ERCC5 (0.53) | ERCC5FEN1RAB9AMEN1KMT2A | |
| SCHEMBL2869896 | 0.82 | FEN1 (0.46) | ERCC5FEN1RAB9AMEN1KMT2A | |
| SCHEMBL29033943 | 0.82 | ERCC5 (0.67) | ERCC5FEN1RAB9AMEN1KMT2A | |
| SCHEMBL4020872 | 0.82 | ERCC5 (0.72) | ERCC5FEN1RAB9AMEN1KMT2A | |
| SCHEMBL8178866 | 0.81 | MEN1 (0.54) | ERCC5FEN1RAB9AMEN1KMT2A | |
| SCHEMBL30335736 | 0.81 | ERCC5 (0.61) | ERCC5FEN1RAB9AMEN1KMT2A | |
| SCHEMBL853580 | 0.81 | ERCC5 (0.61) | ERCC5FEN1RAB9AMEN1KMT2A | |
| SCHEMBL30802824 | 0.80 | ERCC5 (0.65) | ERCC5FEN1RAB9AMEN1KMT2A | |
| SCHEMBL2492019 | 0.80 | ERCC5 (0.65) | ERCC5FEN1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108203408-B | Pyrazole compound containing N-aryl sulfonate as well as synthesis and application thereof | 兰州大学 | 2020-07-21 | — | — | CN | disclosed |
| US-8962834-B2 | Modulators of amyloid beta | HOFFMANN-LA ROCHE INC. (US) | 2015-02-24 | — | — | US | disclosed |
| EP-2257541-B1 | MODULATORS FOR AMYLOID BETA | HOFFMANN LA ROCHE (CH) | 2013-08-14 | — | — | EP | disclosed |
| US-20130190302-A1 | MODULATORS OF AMYLOID BETA | HOFFMANN-LA ROCHE INC. (US) | 2013-07-25 | — | — | US | disclosed |
| US-8034940-B2 | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-10-11 | — | — | US | disclosed |
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| US-20090215759-A1 | MODULATORS FOR AMYLOID BETA | HOFFMANN-LA ROCHE, INC. | 2009-08-27 | — | — | US | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |
| EP-2049507-A2 | MODULATORS OF GLUCOCORTICOID RECEPTOR, AND/OR AP-1, AND/OR NF-KB ACTIVITY AND USE THEREOF | Brystol-Myers Squibb Company (US) | 2009-04-22 | — | — | EP | disclosed |
| US-20090075995-A1 | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2009-03-19 | — | — | US | disclosed |
| US-4508730-A | 1,7-Dihydro-pyrrolo[3,4-e][1,4]diazepin-2(3H)-one derivatives a process for preparing them and their use as anticonvulsant and anti-anxiety agents | GRUPPO LEPETIT S.P.A. (IT) | 1985-04-02 | — | — | US | disclosed |
| EP-0102602-A1 | 1,7-Dihydro-pyrrolo(3,4-e)(1,4)Diazepin-2(3H)-one derivatives, a process for preparing them and their use as anticonvulsant and antianxiety agents | GRUPPO LEPETIT S.p.A. (IT) | 1984-03-14 | — | — | EP | disclosed |
| US-4402970-A | ANTICONVULSANTS, TRANQUILLIZERS | GRUPPO LEPETIT S.P.A. (IT) | 1983-09-06 | — | — | US | disclosed |
| EP-0066762-A2 | 1,7-Dihydro-pyrrolo(3,4-e)(1,4)diazepin-2(1H)-one derivatives | GRUPPO LEPETIT S.P.A. (IT) | 1982-12-15 | — | — | EP | disclosed |
| US-4212806-A | ANTIINFLAMMATORY, ANTIPYRETIC, ANALGESIC, ANTIDEPRESSANT | GRUPPO LEPETIT S.P.A. (IT) | 1980-07-15 | — | — | US | disclosed |
| US-4211709-A | ANTIINFLAMMATORY AGENTS, CENTRAL NERVOUS SYSTEM DEPRESSANTS | GRUPPO LEPETIT S.P.A. (IT) | 1980-07-08 | — | — | US | disclosed |
| US-4211708-A | ANTIINFLAMMATORY AGENTS, CENTRAL NERVOUS SYSTEM DEPRESSANTS | GRUPPO LEPETIT S.P.A. (IT) | 1980-07-08 | — | — | US | disclosed |
| US-4198502-A | ANTIINFLAMMATORY AGENT, CNS DEPRESSANTS, ANALGESICS, ANTIPYRETICS, ANTIULCER AGENTS | GRUPPO LEPETIT S.P.A. (IT) | 1980-04-15 | — | — | US | disclosed |
| US-4140696-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIPYRETICS AND CNS DEPRESSANTS | GRUPPO LEPETIT S.P.A. (IT) | 1979-02-20 | — | — | US | disclosed |
| US-3946057-A | ALKYLENE OXIDE, METAL HALIDE, POLAR SOLVENT | UNION CARBIDE CORPORATION (US) | 1976-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090075995-A1 | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF | NFKB2, NFRKB, NFKB1 | ERCC5 4344/4885FEN1 2746/4885RAB9A 1324/4885 |
| US-20090215759-A1 | MODULATORS FOR AMYLOID BETA | APP, PSEN1, APOB | ERCC5 3483/4885FEN1 3946/4885RAB9A 3008/4885 |
| US-20130190302-A1 | MODULATORS OF AMYLOID BETA | APP, PSEN1, APOB | ERCC5 3361/4885FEN1 3870/4885RAB9A 3002/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.