Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN3 | Q9UGI6 | 2/20 | 0.51 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | BCL6 | P41182 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2521840 | 0.92 | KCNN2 (0.55) | KCNN3KCNN2MAPK14ALOX15LMNA | |
| SCHEMBL2516946 | 0.89 | KCNN3 (0.51) | KCNN3KCNN2MAPK14ALOX15LMNA | |
| SCHEMBL2517763 | 0.86 | KCNN3 (0.54) | KCNN3KCNN2MAPK14ALOX15LMNA | |
| SCHEMBL12205063 | 0.81 | KCNN3 (0.49) | KCNN3KCNN2MAPK14ALOX15LMNA | |
| SCHEMBL30421528 | 0.69 | KCNN3 (1.00) | KCNN3KCNN2ALOX15LMNASMN1; SMN2 | |
| SCHEMBL183176 | 0.69 | KCNN3 (1.00) | KCNN3KCNN2ALOX15LMNASMN1; SMN2 | |
| SCHEMBL244351 | 0.68 | KCNN3 (0.50) | KCNN3KCNN2MAPK14SMN1; SMN2NPSR1 | |
| SCHEMBL183346 | 0.68 | KCNN3 (0.66) | KCNN3KCNN2ALOX15LMNASMN1; SMN2 | |
| SCHEMBL3238040 | 0.68 | KCNN3 (0.66) | KCNN3KCNN2ALOX15LMNASMN1; SMN2 | |
| SCHEMBL3600409 | 0.68 | MAPK14 (0.40) | MAPK14ALOX15LMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268838-B2 | Substituted purinyl-pyrazole derivatives and their use as potassium channel modulators | NEUROSEARCH A/S (DK) | 2012-09-18 | — | — | US | claimed |
| US-20110251217-A1 | SUBSTITUTED PURINYL-PYRAZOL DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2011-10-13 | — | — | US | claimed |
| US-8268838-B2 | Substituted purinyl-pyrazole derivatives and their use as potassium channel modulators | NEUROSEARCH A/S (DK) | 2012-09-18 | — | — | US | disclosed |
| US-8268838-B2 | Substituted purinyl-pyrazole derivatives and their use as potassium channel modulators | NEUROSEARCH A/S (DK) | 2012-09-18 | — | — | US | disclosed |
| US-8268838-B2 | Substituted purinyl-pyrazole derivatives and their use as potassium channel modulators | NEUROSEARCH A/S (DK) | 2012-09-18 | — | — | US | disclosed |
| US-20110251217-A1 | SUBSTITUTED PURINYL-PYRAZOL DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2011-10-13 | — | — | US | disclosed |
| US-20110251217-A1 | SUBSTITUTED PURINYL-PYRAZOL DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2011-10-13 | — | — | US | disclosed |
| US-20110251217-A1 | SUBSTITUTED PURINYL-PYRAZOL DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2011-10-13 | — | — | US | disclosed |
| WO-2010034707-A1 | SUBSTITUTED PURINYL-PYRAZOL DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-04-01 | — | — | WO | disclosed |
| WO-2010034707-A1 | SUBSTITUTED PURINYL-PYRAZOL DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251217-A1 | SUBSTITUTED PURINYL-PYRAZOL DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | KCNJ2, KCNJ5, KCNJ3 | KCNN3 7/4885KCNN2 9/4885MAPK14 607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.