SCHEMBL25196675

SCHEMBL25196675

COc1ccc(/C=C/C(=O)c2ccc(O)cc2O)cc1COc1cc(C)ccc1[N+](=O)[O-]

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP19A1 P11511 1/20 0.58
▸ ALDH1A1 P00352 5/20 0.57
▸ KMT2A Q03164 5/20 0.57
▸ MEN1 O00255 4/20 0.57
▸ ABCG2 Q9UNQ0 3/20 0.57
▸ HPGD P15428 3/20 0.57
▸ MAPT P10636 3/20 0.57
▸ TDP1 Q9NUW8 2/20 0.57
▸ TP53 P04637 2/20 0.57
▸ CYP3A4 P08684 2/20 0.57
▸ ALOX15 P16050 2/20 0.57
▸ MAPK1 P28482 2/20 0.57
▸ ALOX12 P18054 1/20 0.57
▸ SMN1; SMN2 Q16637 1/20 0.57
▸ LMNA P02545 4/20 0.55
▸ CYP1A2 P05177 1/20 0.55
▸ CYP2D6 P10635 1/20 0.55
▸ CYP2C9 P11712 1/20 0.55
▸ CYP2C19 P33261 1/20 0.55
▸ NFKB1 P19838 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25195698 0.94 ALDH1A1 (0.63) CYP19A1ALDH1A1KMT2AMEN1ABCG2
SCHEMBL25184962 0.90 CYP19A1 (0.58) CYP19A1ALDH1A1KMT2AMEN1ABCG2
SCHEMBL25214756 0.89 CYP19A1 (0.60) CYP19A1ALDH1A1KMT2AMEN1ABCG2
SCHEMBL25223533 0.88 ALDH1A1 (0.60) ALDH1A1KMT2AMEN1HPGDMAPT
SCHEMBL25284637 0.88 ALDH1A1 (0.60) ALDH1A1KMT2AMEN1HPGDMAPT
SCHEMBL25204093 0.88 ALDH1A1 (0.64) CYP19A1ALDH1A1KMT2AMEN1ABCG2
SCHEMBL25198483 0.87 CYP19A1 (0.64) CYP19A1ALDH1A1KMT2AMEN1ABCG2
SCHEMBL25208941 0.86 CYP19A1 (0.63) CYP19A1ALDH1A1KMT2AMEN1ABCG2
SCHEMBL30383534 0.86 CYP19A1 (0.63) CYP19A1ALDH1A1KMT2AMEN1ABCG2
SCHEMBL25285463 0.84 CYP19A1 (0.58) CYP19A1ALDH1A1KMT2AMEN1ABCG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 — — US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 — — US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 — — WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 — — EP disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 — — US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B CYP19A1 270/4885ALDH1A1 3285/4885KMT2A 2792/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 CYP19A1 320/4885ALDH1A1 3081/4885KMT2A 3188/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 CYP19A1 320/4885ALDH1A1 3081/4885KMT2A 3188/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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