Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 2/20 | 0.36 |
| ▸ | GABRD | O14764 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.36 |
| ▸ | GABRE | P78334 | 2/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.36 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.36 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.36 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.36 |
| ▸ | XPO1 | O14980 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2518980 | 0.85 | GABRP (0.50) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Fluoride SCHEMBL2519874 | 0.83 | GABRP (0.49) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL27417425 | 0.72 | KEAP1 (0.38) | XPO1MAPTSLC6A12 | |
| SCHEMBL26448756 | 0.70 | TAAR1 (0.36) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL27491244 | 0.68 | GABRP (0.57) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL3534467 | 0.67 | HTT (0.39) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL2519870 | 0.67 | ALDH1A1 (0.32) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1816798 | 0.66 | CYP2C9 (0.38) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1801333 | 0.66 | MAPT (0.41) | XPO1MAPT | |
| SCHEMBL1969600 | 0.66 | GABRP (0.72) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101815715-B | Derivatives of 7-alkynyl-1, 8-naphthyridinones, preparation thereof and use thereof in therapeutics | SANOFI-AVENTIS (FR) | 2014-10-08 | — | — | CN | disclosed |
| US-8586602-B2 | Derivatives of 7 alkynyl-1,8 naphthyridones, preparation method thereof and use of same in therapeutics | SANOFI (FR) | 2013-11-19 | — | — | US | disclosed |
| US-8470847-B2 | Derivatives of 7-alkynyl-1,8-naphthyridones, preparation method thereof and use of same in therapeutics | SANOFI (FR) | 2013-06-25 | — | — | US | disclosed |
| CN-101679427-B | Derivatives of 7-alkynyl-1, 8-naphthyridinones, preparation thereof and use thereof in therapeutics | SANOFI AVENTIS | 2013-02-20 | — | — | CN | disclosed |
| US-20120238598-A1 | DERIVATIVES OF 7 ALKYNYL-1,8 NAPHTHYRIDONES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2012-09-20 | — | — | US | disclosed |
| US-8263614-B2 | Derivatives of 7-alkynyl-1,8-naphthyridones, preparation method thereof and use of same in therapeutics | SANOFI-AVENTIS (FR) | 2012-09-11 | — | — | US | disclosed |
| US-20110251194-A1 | ANTINEOPLASTIC DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-10-13 | — | — | US | disclosed |
| CN-102149706-A | Antitumor derivatives of 4-oxo-L, 4-dihydro-quinoline, preparation method and therapeutic use thereof | SANOFI AVENTIS | 2011-08-10 | — | — | CN | disclosed |
| CN-101815715-A | Derivatives of 7-alkynyl-1, 8-naphthyridinones, preparation thereof and use thereof in therapeutics | SANOFI AVENTIS | 2010-08-25 | — | — | CN | disclosed |
| US-20100144757-A1 | DERIVATIVES OF 7-ALKYNYL-1,8-NAPHTHYRIDONES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2010-06-10 | — | — | US | disclosed |
| US-20100144782-A1 | DERIVATIVES OF 7-ALKYNYL-1,8-NAPHTHYRIDONES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2010-06-10 | — | — | US | disclosed |
| CN-101679427-A | Derivatives of 7-alkynyl-1, 8-naphthyridinones, preparation thereof and use thereof in therapeutics | SANOFI AVENTIS | 2010-03-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144757-A1 | DERIVATIVES OF 7-ALKYNYL-1,8-NAPHTHYRIDONES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | ALK, ABL1, SMPD1 | GABRP 4637/4885GABRD 4511/4885GABRA1 3630/4885 |
| US-20110251194-A1 | ANTINEOPLASTIC DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | MCL1, PAICS, SLCO1B1 | GABRP 2696/4885GABRD 2015/4885GABRA1 1650/4885 |
| US-20100144782-A1 | DERIVATIVES OF 7-ALKYNYL-1,8-NAPHTHYRIDONES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | ALK, ABL1, NTPCR | GABRP 4628/4885GABRD 4459/4885GABRA1 3605/4885 |
| US-20120238598-A1 | DERIVATIVES OF 7 ALKYNYL-1,8 NAPHTHYRIDONES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | FLT4, ALK, KDR | GABRP 4513/4885GABRD 4600/4885GABRA1 3955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.