SCHEMBL25199493

SCHEMBL25199493

O=C(O)c1ccc(/C=C/C(=O)c2ccc(Cl)cc2Cl)cc1

nearest known ligand 0.59

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SRD5A2 P31213 1/20 0.59
CXCL12 P48061 2/20 0.57
MAOB P27338 6/20 0.54
MAOA P21397 3/20 0.54
AR P10275 2/20 0.54
ABCG2 Q9UNQ0 1/20 0.54
DHODH Q02127 1/20 0.53
APP P05067 1/20 0.53
HDAC4 P56524 1/20 0.53
HDAC1 Q13547 1/20 0.53
TSHR P16473 1/20 0.53
CASP1 P29466 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
CYP1B1 Q16678 1/20 0.53
NPC1 O15118 1/20 0.51
RAB9A P51151 1/20 0.51
GUSB P08236 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25197758 1.00 SRD5A2 (0.59) SRD5A2CXCL12MAOBMAOAAR
SCHEMBL29632027 0.86 AR (0.70) CXCL12MAOBMAOAARABCG2
SCHEMBL22264064 0.86 AR (0.70) CXCL12MAOBMAOAARABCG2
SCHEMBL25198960 0.85 AR (0.73) CXCL12MAOBMAOAARABCG2
SCHEMBL28906329 0.84 AR (0.76) MAOBMAOAARDHODHNPC1
SCHEMBL25194322 0.82 PTGS1 (0.62) CXCL12MAOBMAOAARABCG2
SCHEMBL25201291 0.82 PTGS1 (0.62) CXCL12MAOBMAOAARABCG2
SCHEMBL25190973 0.81 MAOB (0.77) CXCL12MAOBMAOADHODHTSHR
SCHEMBL11486409 0.81 MAOB (0.77) CXCL12MAOBMAOADHODHTSHR
SCHEMBL11486412 0.81 MAOB (0.77) CXCL12MAOBMAOADHODHTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 WO disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B SRD5A2 1989/4885CXCL12 399/4885MAOB 1004/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 SRD5A2 3242/4885CXCL12 287/4885MAOB 2435/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 SRD5A2 3242/4885CXCL12 287/4885MAOB 2435/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.