SCHEMBL11486409

SCHEMBL11486409

O=C(O)c1ccc(C(=O)/C=C/c2ccc(Cl)cc2)cc1

nearest known ligand 0.77

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MAOB P27338 9/20 0.77
CYP1B1 Q16678 1/20 0.77
CXCL12 P48061 2/20 0.75
MAOA P21397 3/20 0.73
DHODH Q02127 1/20 0.66
XDH P47989 1/20 0.64
ALOX15 P16050 1/20 0.61
TSHR P16473 1/20 0.61
F3 P13726 1/20 0.59
CYP1A2 P05177 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25190973 1.00 MAOB (0.77) MAOBCYP1B1CXCL12MAOADHODH
SCHEMBL11486412 1.00 MAOB (0.77) MAOBCYP1B1CXCL12MAOADHODH
SCHEMBL25202083 1.00 MAOB (0.77) MAOBCYP1B1CXCL12MAOADHODH
4',4-Dichlorochalcone SCHEMBL659210 0.93 MAOB (0.86) MAOBCYP1B1CXCL12MAOAF3
4',4-Dichlorochalcone SCHEMBL659211 0.93 MAOB (0.86) MAOBCYP1B1CXCL12MAOAF3
4',4-Dichlorochalcone SCHEMBL11819608 0.91 MAOB (0.83) MAOBCYP1B1CXCL12MAOAF3
4',4-Dichlorochalcone SCHEMBL11819257 0.91 MAOB (0.83) MAOBCYP1B1CXCL12MAOAF3
4',4-Dichlorochalcone SCHEMBL11819602 0.91 MAOB (0.83) MAOBCYP1B1CXCL12MAOAF3
4',4-Dichlorochalcone SCHEMBL11819262 0.91 MAOB (0.83) MAOBCYP1B1CXCL12MAOAF3
SCHEMBL25201250 0.91 XDH (0.74) MAOBCYP1B1CXCL12MAOAXDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 EP disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed
US-4219477-A Penicillin derivatives NIPPON CHEMIPHAR COMPANY LIMITED (JP) 1980-08-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B MAOB 1004/4885CYP1B1 230/4885CXCL12 399/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 MAOB 2435/4885CYP1B1 1027/4885CXCL12 287/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 MAOB 2435/4885CYP1B1 1027/4885CXCL12 287/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.