SCHEMBL25199712

SCHEMBL25199712

O=C(/C=C/c1ccc(Cl)cc1)c1ccc(O)cc1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 6/20 1.00
MAOA P21397 4/20 1.00
ABCG2 Q9UNQ0 3/20 1.00
CYP3A4 P08684 4/20 0.82
MEN1 O00255 4/20 0.82
KMT2A Q03164 4/20 0.82
NFKB1 P19838 3/20 0.82
MAPT P10636 3/20 0.82
HPGD P15428 3/20 0.82
ALOX15 P16050 3/20 0.82
MAPK1 P28482 3/20 0.82
HSD17B10 Q99714 3/20 0.82
CYP2C9 P11712 2/20 0.82
CYP2C19 P33261 2/20 0.82
TDP1 Q9NUW8 2/20 0.82
AKR1B1 P15121 2/20 0.82
HSD17B2 P37059 2/20 0.82
NFKB2 Q00653 2/20 0.82
RELA Q04206 2/20 0.82
LMNA P02545 2/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25211947 1.00 MAOB (1.00) MAOBMAOAABCG2CYP3A4MEN1
SCHEMBL31233416 1.00 MAOB (1.00) MAOBMAOAABCG2CYP3A4MEN1
SCHEMBL25208375 0.92 MEN1 (0.96) MAOBMAOAABCG2CYP3A4MEN1
SCHEMBL25198299 0.90 MAOB (0.82) MAOBMAOAABCG2CYP3A4MEN1
SCHEMBL25197325 0.90 MAOB (0.82) MAOBMAOAABCG2CYP3A4MEN1
Isoliquiritigenin SCHEMBL161169 0.90 CYP3A4 (1.00) MAOBMAOAABCG2CYP3A4MEN1
Isoliquiritigenin SCHEMBL10408923 0.90 CYP3A4 (1.00) MAOBMAOAABCG2CYP3A4MEN1
Isoliquiritigenin SCHEMBL161168 0.90 CYP3A4 (1.00) MAOBMAOAABCG2CYP3A4MEN1
Isoliquiritigenin SCHEMBL29522737 0.90 CYP3A4 (1.00) MAOBMAOAABCG2CYP3A4MEN1
Isoliquiritigenin SCHEMBL29396382 0.90 CYP3A4 (1.00) MAOBMAOAABCG2CYP3A4MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 EP disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B MAOB 1004/4885MAOA 1902/4885ABCG2 1606/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 MAOB 2435/4885MAOA 3145/4885ABCG2 3622/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 MAOB 2435/4885MAOA 3145/4885ABCG2 3622/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.