Isoliquiritigenin

Isoliquiritigenin

SCHEMBL29396382

O=C(/C=C/c1ccc(O)cc1)c1ccc(O)cc1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 6/20 1.00
MEN1 O00255 6/20 1.00
KMT2A Q03164 6/20 1.00
MAPT P10636 5/20 1.00
HPGD P15428 5/20 1.00
ALOX15 P16050 5/20 1.00
MAPK1 P28482 5/20 1.00
TDP1 Q9NUW8 4/20 1.00
TP53 P04637 4/20 1.00
NFKB1 P19838 3/20 1.00
HSD17B10 Q99714 3/20 1.00
CYP2C9 P11712 2/20 1.00
CYP2C19 P33261 2/20 1.00
AKR1B1 P15121 2/20 1.00
HSD17B2 P37059 2/20 1.00
NFKB2 Q00653 2/20 1.00
RELA Q04206 2/20 1.00
LMNA P02545 2/20 1.00
CHRNA7 P36544 2/20 1.00
GMNN O75496 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Isoliquiritigenin SCHEMBL29522737 1.00 CYP3A4 (1.00) CYP3A4MEN1KMT2AMAPTHPGD
Isoliquiritigenin SCHEMBL30383629 1.00 CYP3A4 (1.00) CYP3A4MEN1KMT2AMAPTHPGD
Isoliquiritigenin SCHEMBL161169 1.00 CYP3A4 (1.00) CYP3A4MEN1KMT2AMAPTHPGD
Isoliquiritigenin SCHEMBL161168 1.00 CYP3A4 (1.00) CYP3A4MEN1KMT2AMAPTHPGD
Isoliquiritigenin SCHEMBL10408923 1.00 CYP3A4 (1.00) CYP3A4MEN1KMT2AMAPTHPGD
Isoliquiritigenin SCHEMBL25206430 0.98 CYP3A4 (0.97) CYP3A4MEN1KMT2AMAPTHPGD
SCHEMBL25208375 0.98 MEN1 (0.96) CYP3A4MEN1KMT2AMAPTHPGD
SCHEMBL25188827 0.92 CYP3A4 (0.84) CYP3A4MEN1KMT2AMAPTHPGD
SCHEMBL28084572 0.92 CYP3A4 (0.84) CYP3A4MEN1KMT2AMAPTHPGD
SCHEMBL23303982 0.90 CYP3A4 (0.82) CYP3A4MEN1KMT2AMAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4680720-A1 OPTIMIZED PRODUCTION OF BRANCH POINT COMPOUNDS AND DERIVATIVES USING ALTERNATIVE ISOPENTENYL DIPHOSPHATE-SUPPLYING PATHWAYS EvodiaBio ApS (DK) 2026-01-21 EP claimed
US-12529077-B2 Production of geranyl diphosphate-derived compounds Københavns Universitet (DK) 2026-01-20 US claimed
EP-3972833-B1 METHOD OF PLASTICIZING AND DENSIFYING HYDROPHILIC POLYMERIC BIOMATERIALS AND HYDROPHILIC POLYMERIC BIOMATERIALS NEYSES BENEDIKT MATTHIAS (SE) 2025-09-10 EP claimed
EP-2603098-B1 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER FIRMENICH INCORPORATED (US) 2025-08-06 EP claimed
WO-2024189183-A1 OPTIMIZED PRODUCTION OF BRANCH POINT COMPOUNDS AND DERIVATIVES USING ALTERNATIVE ISOPENTENYL DIPHOSPHATE-SUPPLYING PATHWAYS EVODIABIO APS (DK) 2024-09-19 WO claimed
CN-117247601-A Polyion liquid/boron nitride nanosheet composite flame retardant as well as preparation method and application thereof 北京服装学院 2023-12-19 CN claimed
US-20230159960-A1 Production Of Geranyl Diphosphate-Derived Compounds KOBENHAVNS UNIVERSITET (DK) 2023-05-25 US claimed
US-20260116986-A1 EPO RECEPTOR AGONISTS AND ANTAGONISTS IMMUNEDGE INC (US) 2026-04-30 US disclosed
US-20260091067-A1 METHODS AND USES OF MICROBIOME COMPOSITIONS, COMPONENTS, OR METABOLITES FOR TREATING INSULIN-ASSOCIATED DISEASES MARVELBIOME INC (US) 2026-04-02 US disclosed
WO-2026042045-A1 INDOLICIDINE-CONTAINING COMPOSITIONS FOR PERSONAL CARE/HYGIENE APPLICATIONS ITC LIMITED (IN) 2026-02-26 WO disclosed
US-20250290034-A1 METHOD FOR PRODUCING NAÏVE PLURIPOTENT STEM CELLS KYOTO UNIVERSITY (JP) 2025-09-18 US disclosed
EP-4587116-A2 METHODS AND USES OF MICROBIOME COMPOSITIONS, COMPONENTS, OR METABOLITES FOR TREATING INSULIN-ASSOCIATED DISEASES MarvelBiome, Inc. (US) 2025-07-23 EP disclosed
EP-4582534-A1 METHOD FOR PRODUCING NAÏVE PLURIPOTENT STEM CELLS Kyoto University (JP) 2025-07-09 EP disclosed
CN-111229320-B Metal organic framework composite material grafted with ionic liquid and preparation method and application thereof 辽宁大学 2022-07-19 CN disclosed
US-20220184020-A1 Polyphenols as Modulators of Platelet Function THE BRIGHAM AND WOMEN'S HOSPITAL, INC. 2022-06-16 US disclosed
US-20220119840-A1 CLOSED-ENDED DNA (CEDNA) AND USE IN METHODS OF REDUCING GENE OR NUCLEIC ACID THERAPY RELATED IMMUNE RESPONSE GENERATION BIO CO. 2022-04-21 US disclosed
CN-111624271-B Liquid chromatography method for detecting corresponding substance of peony and licorice decoction, standard fingerprint spectrum and application 厦门中药厂有限公司 2022-03-18 CN disclosed
US-20220064173-A1 INHIBITORS OF NEK7 KINASE HALIA THERAPEUTICS INC (US) 2022-03-03 US disclosed
CN-110117326-B Xanthohumol-related protein and application thereof in stabilizing product in xanthohumol synthesis pathway 中国科学院遗传与发育生物学研究所 2022-03-01 CN disclosed
CN-110117327-B Xanthohumol-related protein and application thereof in preparation of product in xanthohumol synthesis pathway 中国科学院遗传与发育生物学研究所 2022-02-25 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12529077-B2 Production of geranyl diphosphate-derived compounds GGPS1, OGA, GBA3 CYP3A4 224/4885MEN1 4421/4885KMT2A 3786/4885
US-20220119840-A1 CLOSED-ENDED DNA (CEDNA) AND USE IN METHODS OF REDUCING GENE OR NUCLEIC ACID THERAPY RELATED IMMUNE RESPONSE STING1, DCLRE1B, DCLRE1A CYP3A4 4882/4885MEN1 3970/4885KMT2A 1183/4885
US-20260091067-A1 METHODS AND USES OF MICROBIOME COMPOSITIONS, COMPONENTS, OR METABOLITES FOR TREATING INSULIN-ASSOCIATED DISEASES IAPP, GPR119, FAHD1 CYP3A4 1976/4885MEN1 361/4885KMT2A 2945/4885
US-20260116986-A1 EPO RECEPTOR AGONISTS AND ANTAGONISTS EPOR, STAT5A, JAK2 CYP3A4 4330/4885MEN1 3558/4885KMT2A 1468/4885
US-20220064173-A1 INHIBITORS OF NEK7 KINASE NEK7, NEK1, NEK5 CYP3A4 2521/4885MEN1 1766/4885KMT2A 2554/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.