SCHEMBL25200094

SCHEMBL25200094

C[Si](C)(C)C#Cc1ccnc(F)c1

nearest known ligand 0.44

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 1/20 0.44
LOXL2 Q9Y4K0 1/20 0.37
GRM5 P41594 5/20 0.36
IDO1 P14902 1/20 0.32
GABRA1 P14867 3/20 0.31
GABRG2 P18507 3/20 0.31
GABRB3 P28472 3/20 0.31
GABRA5 P31644 3/20 0.31
GABRA3 P34903 3/20 0.31
GABRA2 P47869 3/20 0.31
GABRA4 P48169 2/20 0.31
GABRA6 Q16445 2/20 0.31
KCNH2 Q12809 1/20 0.31
PIK3CG P48736 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30527105 0.78 FFAR1 (0.45) FFAR1GRM5GABRA1GABRG2GABRB3
SCHEMBL4630923 0.78 FFAR1 (0.45) FFAR1GRM5GABRA1GABRG2GABRB3
SCHEMBL4034902 0.77 NOS3 (0.45) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL19401536 0.77 IDO1 (0.32) FFAR1IDO1GABRA1GABRG2GABRB3
SCHEMBL39723 0.77 FFAR1 (0.44) FFAR1LOXL2GRM5IDO1KCNH2
SCHEMBL3645150 0.77 GABRA1 (0.33) FFAR1GABRA1GABRG2GABRB3GABRA5
SCHEMBL20602050 0.77 SMARCA2 (0.34)
SCHEMBL20602306 0.77 LOXL2 (0.42) LOXL2IDO1GABRA1GABRG2GABRB3
SCHEMBL17478024 0.76 TYK2 (0.34) GRM5GABRA1GABRG2GABRB3GABRA5
SCHEMBL23918702 0.74 FFAR1 (0.56) FFAR1GRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023093728-A1 BRM SELECTIVE DEGRADATION AGENT COMPOUND AND USE THEREOF 江苏先声药业有限公司 2023-06-01 WO disclosed
WO-2023093728-A1 BRM SELECTIVE DEGRADATION AGENT COMPOUND AND USE THEREOF 江苏先声药业有限公司 2023-06-01 WO disclosed
CN-109293652-B Substituted thiazole derivative and application thereof 四川科伦博泰生物医药股份有限公司 2021-10-22 CN disclosed