Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | TYMS | P04818 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NNMT | P40261 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30375367 | 1.00 | ALDH1A1 (0.41) | ALDH1A1HSD17B10TDP1PARP1PRKCI | |
| SCHEMBL25180455 | 0.83 | HAO1 (0.44) | ALDH1A1HSD17B10TDP1PARP1PRKCI | |
| SCHEMBL30375027 | 0.83 | HAO1 (0.44) | ALDH1A1HSD17B10TDP1PARP1PRKCI | |
| SCHEMBL25183965 | 0.78 | NAMPT (0.40) | ALDH1A1HSD17B10TDP1PARP1PRKCI | |
| SCHEMBL30375344 | 0.78 | NAMPT (0.40) | ALDH1A1HSD17B10TDP1PARP1PRKCI | |
| SCHEMBL25183266 | 0.76 | ALDH1A1 (0.57) | ALDH1A1HSD17B10TDP1PARP1PRKCI | |
| SCHEMBL30375279 | 0.76 | ALDH1A1 (0.57) | ALDH1A1HSD17B10TDP1PARP1PRKCI | |
| SCHEMBL1009542 | 0.73 | HSD17B10 (0.51) | ALDH1A1HSD17B10TDP1PARP1PRKCI | |
| SCHEMBL25202577 | 0.73 | ALDH1A1 (0.42) | ALDH1A1HSD17B10TDP1PARP1PRKCI | |
| SCHEMBL30375154 | 0.73 | ALDH1A1 (0.42) | ALDH1A1HSD17B10TDP1PARP1PRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4426681-A1 | PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS | Sitryx Therapeutics Limited (GB) | 2024-09-11 | — | — | EP | disclosed |
| CN-118317951-A | Phthalazine derivatives as pyruvate kinase modulators | 西特瑞治疗有限公司 | 2024-07-09 | — | — | CN | disclosed |
| WO-2023079294-A1 | PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS | SITRYX THERAPEUTICS LIMITED (GB) | 2023-05-11 | — | — | WO | disclosed |
| WO-2023079294-A1 | PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS | SITRYX THERAPEUTICS LIMITED (GB) | 2023-05-11 | — | — | WO | disclosed |