SCHEMBL25202062

SCHEMBL25202062

COc1ccc2cc(/C=C/C(=O)c3ccccc3O)ccc2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 5/20 1.00
MAPT P10636 5/20 0.80
MAOA P21397 2/20 0.80
CYP2C19 P33261 2/20 0.80
CYP2D6 P10635 1/20 0.80
CYP2C9 P11712 1/20 0.80
CASP3 P42574 1/20 0.80
SENP8 Q96LD8 1/20 0.80
SENP7 Q9BQF6 1/20 0.80
SENP6 Q9GZR1 1/20 0.80
ABCG2 Q9UNQ0 4/20 0.70
PTGS1 P23219 2/20 0.70
PTGS2 P35354 2/20 0.70
ACHE P22303 1/20 0.70
LMNA P02545 2/20 0.67
NPC1 O15118 1/20 0.67
RECQL P46063 1/20 0.67
RAB9A P51151 1/20 0.67
ATM Q13315 1/20 0.67
L3MBTL1 Q9Y468 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2807599 0.89 MAPT (1.00) MAOBMAPTMAOACYP2C19CYP2D6
SCHEMBL30807155 0.89 MAPT (1.00) MAOBMAPTMAOACYP2C19CYP2D6
SCHEMBL2807601 0.89 MAPT (1.00) MAOBMAPTMAOACYP2C19CYP2D6
SCHEMBL5085597 0.88 MAOB (1.00) MAOBMAPTMAOACYP2C19CYP2D6
SCHEMBL5085601 0.88 MAOB (1.00) MAOBMAPTMAOACYP2C19CYP2D6
SCHEMBL25225627 0.88 MAOB (1.00) MAOBMAPTMAOACYP2C19CYP2D6
SCHEMBL30384259 0.88 MAOB (1.00) MAOBMAPTMAOACYP2C19CYP2D6
SCHEMBL17220851 0.87 MAOB (0.77) MAOBMAPTMAOACYP2C19CYP2D6
SCHEMBL17220854 0.87 MAOB (0.77) MAOBMAPTMAOACYP2C19CYP2D6
SCHEMBL30382854 0.87 MAOB (0.77) MAOBMAPTMAOACYP2C19CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 EP disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B MAOB 1004/4885MAPT 3297/4885MAOA 1902/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 MAOB 2435/4885MAPT 3512/4885MAOA 3145/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 MAOB 2435/4885MAPT 3512/4885MAOA 3145/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.