SCHEMBL252022

SCHEMBL252022

C[Si](C)(C)C#Cc1cc[c]cc1

nearest known ligand 0.36

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 1/20 0.31
GABRG2 P18507 1/20 0.31
GABRB3 P28472 1/20 0.31
GABRA5 P31644 1/20 0.31
GABRA3 P34903 1/20 0.31
GABRA2 P47869 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1306384 0.82 GABRA1 (0.38) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL1306505 0.79 APP (0.41) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL853691 0.76 CYP2A6 (0.48)
SCHEMBL11883827 0.76 APP (0.44)
SCHEMBL5687827 0.76 P2RY6 (0.32)
SCHEMBL241607 0.76 CACNA2D1 (0.33)
SCHEMBL2854252 0.75 CYP1A1 (0.44) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL563613 0.75 APP (0.55)
SCHEMBL973962 0.74
Diphenylacetylene SCHEMBL3842452 0.73 APP (0.60)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 242 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113416138-A Henry type reaction method of iron mediated aldehyde and bromonitromethane and product 南京工业大学 2021-09-21 CN claimed
US-8529996-B2 High-temperature attachment of organic molecules to substrates THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-09-10 US claimed
US-8231941-B2 Procedure for preparing redox-active polymers on surfaces THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-07-31 US claimed
US-20100330284-A1 PROCEDURE FOR PREPARING REDOX-ACTIVE POLYMERS ON SURFACES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2010-12-30 US claimed
EP-1765816-B1 SUBSTITUTED 1-PROPIOLYLPIPERAZINES HAVING AN AFFINITY FOR THE MGLUR5 RECEPTOR IN ORDER TO TREAT PAINFUL CONDITIONS GRUENENTHAL GMBH (DE) 2010-03-10 EP claimed
US-7452572-B1 Procedure for preparing redox-active polymers on surfaces THE NORTH CAROLINA STATE UNIVERSITY (US) 2008-11-18 US claimed
US-20080280047-A1 PROCEDURE FOR PREPARING REDOX-ACTIVE POLYMERS ON SURFACES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2008-11-13 US claimed
US-7300939-B2 Substituted 1-propiolylpiperazine compounds, their preparation and use GRUENENTHAL GMBH (DE) 2007-11-27 US claimed
US-20070212897-A1 HIGH-TEMPERATURE ATTACHMENT OF ORGANIC MOLECULES TO SUBSTRATES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-09-13 US claimed
EP-1809473-A2 PROCEDURE FOR PREPARING REDOX-ACTIVE POLYMERS ON SURFACES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-07-25 EP claimed
US-6943054-B2 Attachment of organic molecules to group III, IV or V substrates THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2005-09-13 US claimed
US-6916982-B2 Synthesis of perylene-porphyrin building blocks and polymers thereof for the production of light-harvesting arrays NORTH CAROLINA STATE UNIVERSITY (US) 2005-07-12 US claimed
WO-2005043583-A2 HIGH-TEMPERATURE ATTACHMENT OF ORGANIC MOLECULES TO SUBSTRATES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2005-05-12 WO claimed
US-20050048691-A1 High temperature attachment of organic molecules to substrates THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2005-03-03 US claimed
US-20050019500-A1 Coupling a heat resistant porphyrins derivatized with an attachment group to a silicon or germanium semiconductor surface by heating to at least 200 degrees Celsius; integrated circuits THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2005-01-27 US claimed
US-6728129-B2 Multistate triple-decker dyads in three distinct architectures for information storage applications THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2004-04-27 US claimed
WO-2003105237-A1 SYNTHESIS OF PERYLENE-PORPHYRIN BUILDING BLOCKS AND POLYMERS THEREOF FOR THE PRODUCTION OF LIGHT-HARVESTING ARRAYS NORTH CAROLINA STATE UNIVERSITY (US) 2003-12-18 WO claimed
US-20030169618-A1 Multistate triple-decker dyads in three distinct architectures for information storage applications THE REGENTS OF THE UNIVERSITY OF CALIFORNIA OFFICE OF TECHNOLOGY TRANSFER 2003-09-11 US claimed
WO-2003071552-A1 MULTISTATE TRIPLE-DECKER DYADS IN THREE DISTINCT ARCHITECTURES FOR INFORMATION STORAGE APPLICATIONS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2003-08-28 WO claimed
US-20030075216-A1 Synthesis of perylene-porphyrin building blocks and polymers thereof for the production of light-harvesting arrays NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2003-04-24 US claimed