Flavokawain B

Flavokawain B

SCHEMBL25202899

COc1cc(O)c(C(=O)C=Cc2ccccc2)c(OC)c1.O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)ccc12

nearest known ligand 0.60

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 6/20 0.60
▸ KMT2A Q03164 6/20 0.60
▸ CYP3A4 P08684 5/20 0.60
▸ HSD17B10 Q99714 4/20 0.60
▸ TP53 P04637 3/20 0.60
▸ ATM Q13315 1/20 0.60
▸ MEN1 O00255 5/20 0.57
▸ KDM4E B2RXH2 4/20 0.57
▸ LMNA P02545 3/20 0.57
▸ HPGD P15428 3/20 0.57
▸ ALDH1A1 P00352 2/20 0.57
▸ ALOX15 P16050 2/20 0.57
▸ MAPK1 P28482 2/20 0.57
▸ CASP1 P29466 2/20 0.57
▸ CASP7 P55210 2/20 0.57
▸ SMN1; SMN2 Q16637 1/20 0.57
▸ ADORA3 P0DMS8 1/20 0.55
▸ CDK5 Q00535 2/20 0.55
▸ CDK5R1 Q15078 2/20 0.55
▸ CYP2C9 P11712 2/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Quercetin SCHEMBL25190629 0.89 KMT2A (0.61) MAPTKMT2ACYP3A4HSD17B10TP53
Flavokawain B SCHEMBL25185055 0.77 MAPT (1.00) MAPTKMT2ACYP3A4HSD17B10TP53
Flavokawain B SCHEMBL30382640 0.77 MAPT (1.00) MAPTKMT2ACYP3A4HSD17B10TP53
Flavokawain B SCHEMBL29439356 0.77 MAPT (1.00) MAPTKMT2ACYP3A4HSD17B10TP53
Flavokawain B SCHEMBL1938260 0.77 MAPT (1.00) MAPTKMT2ACYP3A4HSD17B10TP53
Flavokawain B SCHEMBL1675987 0.77 MAPT (1.00) MAPTKMT2ACYP3A4HSD17B10TP53
Flavokawain B SCHEMBL25265211 0.76 MAPT (0.97) MAPTKMT2ACYP3A4HSD17B10TP53
Flavokawain B SCHEMBL30384635 0.76 MAPT (0.97) MAPTKMT2ACYP3A4HSD17B10TP53
Flavokawain B SCHEMBL25193713 0.76 MAPT (0.97) MAPTKMT2ACYP3A4HSD17B10TP53
SCHEMBL25192230 0.75 MAPT (0.86) MAPTKMT2ACYP3A4HSD17B10TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 — — US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 MAPT 3512/4885KMT2A 3188/4885CYP3A4 1589/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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