Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | MAOA | P21397 | 9/20 | 0.64 |
| ▸ | MAOB | P27338 | 9/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25226367 | 0.81 | POLB (0.74) | POLBMAOAMAOBRXFP1TSHR | |
| SCHEMBL25202045 | 0.81 | POLB (0.74) | POLBMAOAMAOBALDH1A1TSHR | |
| SCHEMBL25210141 | 0.81 | POLB (1.00) | POLBMAOAMAOBALDH1A1RXFP1 | |
| SCHEMBL25205968 | 0.81 | POLB (0.73) | POLBMAOAMAOBALDH1A1RXFP1 | |
| SCHEMBL25204998 | 0.80 | POLB (0.71) | POLBMAOAMAOBRXFP1TSHR | |
| SCHEMBL25236281 | 0.79 | POLB (0.70) | POLBMAOAMAOBALDH1A1RXFP1 | |
| SCHEMBL25206902 | 0.78 | MAOB (1.00) | POLBMAOAMAOBALDH1A1RXFP1 | |
| SCHEMBL25209395 | 0.78 | POLB (0.69) | POLBMAOAMAOBALDH1A1RXFP1 | |
| SCHEMBL25201006 | 0.77 | POLB (0.68) | POLBMAOAMAOBALDH1A1RXFP1 | |
| SCHEMBL21602428 | 0.77 | ALDH1A1 (0.44) | POLBMAOAMAOBALDH1A1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11666577-B2 | MLKL inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2023-06-06 | — | — | US | disclosed |
| CN-110573509-B | MLKL inhibitors | 北京生命科学研究所 | 2023-05-26 | — | — | CN | disclosed |
| CN-110573509-A | MLKL inhibitors | 北京生命科学研究所 | 2019-12-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11666577-B2 | MLKL inhibitors | MLKL, CMKLR1, PCSK9 | POLB 2780/4885MAOA 4584/4885MAOB 4517/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.