SCHEMBL25207644

SCHEMBL25207644

CC1(CNCc2ccccc2)COC1

nearest known ligand 0.52

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
OPRM1 P35372 1/20 0.52
OPRK1 P41145 1/20 0.52
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
MAOA P21397 1/20 0.41
TP53 P04637 1/20 0.41
THRB P10828 1/20 0.41
MAPT P10636 2/20 0.40
CHRM2 P08172 1/20 0.40
GAA P10253 1/20 0.40
KDM4E B2RXH2 1/20 0.39
CYP3A4 P08684 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2019716 0.83 MEN1 (0.50) MEN1KMT2ATDP1MAOATP53
SCHEMBL13573564 0.83 OPRM1 (0.47) OPRM1OPRK1TDP1KDM4ECYP3A4
SCHEMBL29371944 0.83 MEN1 (0.42) OPRM1OPRK1MEN1KMT2ATDP1
Hydrochloric Acid SCHEMBL27690675 0.81 MEN1 (0.48) OPRM1MEN1KMT2ATDP1MAOA
SCHEMBL21193244 0.79 MEN1 (0.45) MEN1KMT2ATDP1MAOATHRB
SCHEMBL23023065 0.79 MEN1 (0.45) MEN1KMT2ATDP1MAOAMAPT
SCHEMBL23023165 0.76 MEN1 (0.42) MEN1KMT2ATDP1MAOATP53
SCHEMBL23023164 0.76 MEN1 (0.42) MEN1KMT2ATDP1MAOATP53
SCHEMBL5028984 0.75 MAOA (0.43) OPRM1OPRK1MAOATP53GAA
SCHEMBL16269419 0.73 SCN8A (0.43) OPRM1OPRK1KMT2ATDP1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250332138-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING MENTAL DISORDER VIVOZON, INC. (KR) 2025-10-30 US disclosed
US-12435051-B2 Dual modulator of mGluR5 and 5-HT2A receptor, and use thereof VIVOZON, INC. (KR) 2025-10-07 US disclosed
EP-4470534-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING MENTAL DISORDER Vivozon, Inc. (KR) 2024-12-04 EP disclosed
US-20240360092-A1 DUAL MODULATOR OF MGLUR5 AND 5-HT2A RECEPTOR, AND USE THEREOF VIVOZON INC. (KR) 2024-10-31 US disclosed
US-12060339-B2 Dual modulator of mGluR5 and 5-HT2A receptor, and use thereof VIVOZON INC. (KR) 2024-08-13 US disclosed
EP-4190770-A1 DUAL REGULATOR FOR MGLUR5 AND 5-HT2A RECEPTORS AND USE THEREOF Vivozon, Inc. (KR) 2023-06-07 EP disclosed
CN-116234552-A Dual modulators of mGluR5 and 5-HT2A receptors and uses thereof (株)倍宝尊 2023-06-06 CN disclosed
US-20220274939-A1 DUAL MODULATOR OF MGLUR5 AND 5-HT2A RECEPTOR, AND USE THEREOF VIVOZON INC. (KR) 2022-09-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12435051-B2 Dual modulator of mGluR5 and 5-HT2A receptor, and use thereof GRM5, HTR5A, HTR2A OPRM1 58/4885OPRK1 60/4885MEN1 4816/4885
US-20240360092-A1 DUAL MODULATOR OF MGLUR5 AND 5-HT2A RECEPTOR, AND USE THEREOF GRM5, HTR5A, HTR2A OPRM1 58/4885OPRK1 60/4885MEN1 4816/4885
US-12060339-B2 Dual modulator of mGluR5 and 5-HT2A receptor, and use thereof GRM5, HTR5A, HTR2A OPRM1 58/4885OPRK1 60/4885MEN1 4816/4885
US-20250332138-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING MENTAL DISORDER GRM5, HTR5A, HTR2A OPRM1 85/4885OPRK1 82/4885MEN1 4437/4885
US-20220274939-A1 DUAL MODULATOR OF MGLUR5 AND 5-HT2A RECEPTOR, AND USE THEREOF GRM5, HTR5A, HTR2A OPRM1 58/4885OPRK1 60/4885MEN1 4816/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.