Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2525284 | 0.98 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2HPGDDDB1CRBN | |
| SCHEMBL27763649 | 0.78 | NCF1 (0.41) | TP53MEN1KMT2AP2RX7KDM4E | |
| SCHEMBL27992672 | 0.77 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2HPGDDDB1CRBN | |
| SCHEMBL2528768 | 0.76 | SIGMAR1 (0.39) | ALDH1A1SMN1; SMN2HPGDOPRM1OPRD1 | |
| Hydrochloric Acid SCHEMBL1697541 | 0.74 | SIGMAR1 (0.38) | ALDH1A1SMN1; SMN2HPGDOPRM1OPRD1 | |
| SCHEMBL14763651 | 0.72 | ALDH1A1 (0.36) | ALDH1A1 | |
| SCHEMBL11995119 | 0.69 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2HPGDDDB1CRBN | |
| SCHEMBL16786521 | 0.69 | DDB1 (0.52) | ALDH1A1SMN1; SMN2HPGDDDB1CRBN | |
| SCHEMBL14763648 | 0.68 | PDCD1 (0.35) | ALDH1A1HPGD | |
| SCHEMBL11188803 | 0.67 | DDB1 (0.42) | ALDH1A1SMN1; SMN2HPGDDDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104566-B1 | OLEFIN METATHESIS INITIATORS BEARING THIAZOL-2-YLIDENE LIGANDS | CALIFORNIA INST OF TECHN (US) | 2016-01-27 | — | — | EP | disclosed |
| US-8039566-B2 | Olefin metathesis initiators bearing thiazol-2-ylidene ligands | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2011-10-18 | — | — | US | disclosed |
| US-20100144987-A1 | OLEFIN METATHESIS INITIATORS BEARING THIAZOL-2-YLIDENE LIGANDS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2010-06-10 | — | — | US | disclosed |
| EP-2104566-A1 | OLEFIN METATHESIS INITIATORS BEARING THIAZOL-2-YLIDENE LIGANDS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008064223-A1 | OLEFIN METATHESIS INITIATORS BEARING THIAZOL-2-YLIDENE LIGANDS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2008-05-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144987-A1 | OLEFIN METATHESIS INITIATORS BEARING THIAZOL-2-YLIDENE LIGANDS | TEC, OXER1, CCNL2 | ALDH1A1 510/4885SMN1; SMN2 4565/4885HPGD 1964/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.