Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.37 |
| ▸ | NEK2 | P51955 | 9/20 | 0.34 |
| ▸ | PLK1 | P53350 | 7/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL216161 | 0.84 | NEK2 (0.33) | CHEK2NEK2PLK1KDR | |
| SCHEMBL215858 | 0.76 | TOP2A (0.35) | — | |
| SCHEMBL213660 | 0.74 | TOP2A (0.35) | — | |
| SCHEMBL216162 | 0.69 | ALDH1A1 (0.39) | KDRL3MBTL1 | |
| SCHEMBL214572 | 0.65 | BTK (0.42) | KDR | |
| SCHEMBL214751 | 0.65 | BTK (0.38) | KDR | |
| SCHEMBL27040144 | 0.64 | AMY1A (0.47) | CHEK2BRD4PDGFRBKDRFGFR1 | |
| SCHEMBL214823 | 0.62 | CHEK2 (0.35) | CHEK2PLK1PLK3 | |
| SCHEMBL214920 | 0.62 | MAPK14 (0.42) | — | |
| Hydrochloric Acid SCHEMBL213800 | 0.62 | CHEK2 (0.35) | CHEK2PLK1PLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088767-B2 | JAK-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-01-03 | — | — | US | claimed |