Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.31 |
| ▸ | SCN4A | P35499 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28579733 | 1.00 | NR1H2 (0.36) | NR1H2NR1H3PTPN1P2RX3UCHL1 | |
| SCHEMBL1269514 | 0.89 | P2RX3 (0.40) | NR1H2NR1H3PTPN1P2RX3UCHL1 | |
| SCHEMBL2387781 | 0.89 | P2RX3 (0.40) | NR1H2NR1H3PTPN1P2RX3UCHL1 | |
| SCHEMBL18577311 | 0.89 | P2RX3 (0.40) | NR1H2NR1H3PTPN1P2RX3UCHL1 | |
| SCHEMBL24826391 | 0.89 | P2RX3 (0.40) | NR1H2NR1H3PTPN1P2RX3UCHL1 | |
| SCHEMBL1269513 | 0.89 | P2RX3 (0.40) | NR1H2NR1H3PTPN1P2RX3UCHL1 | |
| SCHEMBL6624196 | 0.89 | P2RX3 (0.40) | NR1H2NR1H3PTPN1P2RX3UCHL1 | |
| SCHEMBL7456999 | 0.89 | P2RX3 (0.40) | NR1H2NR1H3PTPN1P2RX3UCHL1 | |
| SCHEMBL142967 | 0.89 | P2RX3 (0.40) | NR1H2NR1H3PTPN1P2RX3UCHL1 | |
| SCHEMBL4776880 | 0.88 | FKBP1A (0.39) | P2RX3FKBP1AHSD17B10CYP1A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4295852-A2 | PIPERIDINE DERIVATIVES AS INHIBITORS OF CYCLIN DEPENDENT KINASE 7 (CDK7) | Syros Pharmaceuticals, Inc. (US) | 2023-12-27 | — | — | EP | disclosed |
| EP-3484871-B1 | PIPERIDINE DERIVATIVES AS INHIBITORS OF CYCLIN DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS INC (US) | 2023-06-07 | — | — | EP | disclosed |
| EP-3484871-B1 | PIPERIDINE DERIVATIVES AS INHIBITORS OF CYCLIN DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS INC (US) | 2023-06-07 | — | — | EP | disclosed |