Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 14/20 | 0.64 |
| ▸ | MAPT | P10636 | 12/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 12/20 | 0.64 |
| ▸ | MEN1 | O00255 | 11/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 10/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.64 |
| ▸ | NPC1 | O15118 | 7/20 | 0.64 |
| ▸ | RAB9A | P51151 | 7/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.61 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.61 |
| ▸ | RELA | Q04206 | 5/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.55 |
| ▸ | SENP8 | Q96LD8 | 4/20 | 0.55 |
| ▸ | SENP6 | Q9GZR1 | 4/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2521031 | 1.00 | GAA (0.64) | GAAMAPTKMT2AMEN1TDP1 | |
| SCHEMBL12214431 | 0.83 | SENP7 (0.65) | GAAMAPTKMT2AMEN1TDP1 | |
| SCHEMBL24629292 | 0.79 | GAA (0.75) | GAAMAPTKMT2AMEN1TDP1 | |
| SCHEMBL27135266 | 0.79 | GAA (0.75) | GAAMAPTKMT2AMEN1TDP1 | |
| SCHEMBL30711838 | 0.76 | SENP7 (0.71) | GAAMAPTKMT2AMEN1TDP1 | |
| SCHEMBL27129941 | 0.76 | SENP7 (0.71) | GAAMAPTKMT2AMEN1TDP1 | |
| SCHEMBL24629108 | 0.76 | SENP7 (0.71) | GAAMAPTKMT2AMEN1TDP1 | |
| SCHEMBL5405166 | 0.73 | MAPT (0.65) | GAAMAPTKMT2AMEN1TDP1 | |
| SCHEMBL24629300 | 0.72 | SENP7 (1.00) | GAAMAPTKMT2AMEN1TDP1 | |
| SCHEMBL27139059 | 0.72 | SENP7 (1.00) | GAAMAPTKMT2AMEN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039505-B2 | Compounds for modulating T-cells | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2011-10-18 | — | — | US | disclosed |
| US-8039505-B2 | Compounds for modulating T-cells | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2011-10-18 | — | — | US | disclosed |
| US-8039505-B2 | Compounds for modulating T-cells | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2011-10-18 | — | — | US | disclosed |
| US-20080293739-A1 | COMPOUNDS FOR MODULATING T-CELLS | UNIVERSITY OF UTAH RESEARCH FOUNDATION | 2008-11-27 | — | — | US | disclosed |
| US-20080293739-A1 | COMPOUNDS FOR MODULATING T-CELLS | UNIVERSITY OF UTAH RESEARCH FOUNDATION | 2008-11-27 | — | — | US | disclosed |
| US-20080293739-A1 | COMPOUNDS FOR MODULATING T-CELLS | UNIVERSITY OF UTAH RESEARCH FOUNDATION | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293739-A1 | COMPOUNDS FOR MODULATING T-CELLS | CD4, HLA-DRB1, CD74 | GAA 4266/4885MAPT 3438/4885KMT2A 555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.