Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QRFPR | Q96P65 | 8/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 6/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | GPR183 | P32249 | 1/20 | 0.40 |
| ▸ | SPR | P35270 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30301552 | 1.00 | QRFPR (0.44) | QRFPRTMEM97SIGMAR1KCNH2CYP2D6 | |
| SCHEMBL25216893 | 0.96 | QRFPR (0.48) | QRFPRTMEM97SIGMAR1KCNH2CYP2D6 | |
| SCHEMBL30301571 | 0.96 | QRFPR (0.48) | QRFPRTMEM97SIGMAR1KCNH2CYP2D6 | |
| SCHEMBL30301533 | 0.93 | HSP90AA1 (0.40) | QRFPRTMEM97SIGMAR1KCNH2SPR | |
| SCHEMBL25219116 | 0.93 | HSP90AA1 (0.40) | QRFPRTMEM97SIGMAR1KCNH2SPR | |
| SCHEMBL25669016 | 0.88 | KMT2A (0.45) | TMEM97SIGMAR1GPR183SPRHTR1A | |
| SCHEMBL30368318 | 0.88 | SPR (0.51) | CYP2D6SPRHSP90AA1 | |
| SCHEMBL25669000 | 0.88 | SPR (0.51) | CYP2D6SPRHSP90AA1 | |
| SCHEMBL25249624 | 0.87 | ESR1 (0.41) | TMEM97SIGMAR1CYP2D6ESR1GPR183 | |
| SCHEMBL30368252 | 0.87 | ESR1 (0.41) | TMEM97SIGMAR1CYP2D6ESR1GPR183 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183197-A1 | INHIBITORS OF MLH1 AND/OR PMS2 FOR CANCER TREATMENT | Neophore Limited (GB) | 2023-06-15 | — | — | US | disclosed |
| US-20230183197-A1 | INHIBITORS OF MLH1 AND/OR PMS2 FOR CANCER TREATMENT | Neophore Limited (GB) | 2023-06-15 | — | — | US | disclosed |
| US-20230183197-A1 | INHIBITORS OF MLH1 AND/OR PMS2 FOR CANCER TREATMENT | Neophore Limited (GB) | 2023-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183197-A1 | INHIBITORS OF MLH1 AND/OR PMS2 FOR CANCER TREATMENT | MSH2, PMS2, MSH6 | QRFPR 2617/4885TMEM97 2944/4885SIGMAR1 4819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.