Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenoxylate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 4/20 | 0.69 |
| ▸ | KCNA3 | P22001 | 3/20 | 0.69 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.54 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.54 |
| ▸ | HTR2C | P28335 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.54 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenoxylate SCHEMBL4060051 | 1.00 | OPRM1 (0.69) | OPRM1KCNA3CHRM2CHRM5CHRM1 | |
| Diphenoxylate SCHEMBL16766515 | 0.97 | OPRM1 (0.65) | OPRM1KCNA3CHRM2CHRM5CHRM1 | |
| Diphenoxylate SCHEMBL865011 | 0.97 | OPRM1 (0.64) | OPRM1KCNA3CHRM2CHRM5CHRM1 | |
| Diphenoxylate SCHEMBL1831278 | 0.86 | OPRM1 (0.51) | OPRM1KCNA3CHRM2CHRM5CHRM1 | |
| Diphenoxylate SCHEMBL42940 | 0.83 | OPRM1 (1.00) | OPRM1KCNA3ADRA1ASLC22A1OPRD1 | |
| Diphenoxylate SCHEMBL28596518 | 0.82 | OPRM1 (0.98) | OPRM1KCNA3ADRA1ASLC22A1OPRD1 | |
| Diphenoxylate SCHEMBL42124 | 0.82 | OPRM1 (0.98) | OPRM1KCNA3ADRA1ASLC22A1OPRD1 | |
| Diphenoxylate SCHEMBL28374697 | 0.82 | OPRM1 (0.98) | OPRM1KCNA3ADRA1ASLC22A1OPRD1 | |
| Diphenoxylate SCHEMBL20595320 | 0.82 | OPRM1 (0.98) | OPRM1KCNA3ADRA1ASLC22A1OPRD1 | |
| Diphenoxylate SCHEMBL28385054 | 0.82 | OPRM1 (0.98) | OPRM1KCNA3ADRA1ASLC22A1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008116165-A9 | METHODS AND SYSTEMS OF DELIVERING MEDICATION VIA INHALATION | NEXT SAFETY INC (US) | 2009-06-11 | — | — | WO | claimed |
| WO-2008116165-A2 | METHODS AND SYSTEMS OF DELIVERING MEDICATION VIA INHALATION | NEXT SAFETY, INC. (US) | 2008-09-25 | — | — | WO | claimed |
| US-20080066741-A1 | METHODS AND SYSTEMS OF DELIVERING MEDICATION VIA INHALATION | HUNTER, CHARLES ERIC | 2008-03-20 | — | — | US | claimed |
| US-9554989-B2 | Silk reservoirs for drug delivery | TRUSTEES OF TUFTS COLLEGE (US) | 2017-01-31 | — | — | US | disclosed |
| CN-105687167-A | Extrudable and extruded compositions for delivery of bioactive agents, method of making the same and method of using same | 菲利普莫里斯生产公司 | 2016-06-22 | — | — | CN | disclosed |
| CN-104797240-A | Composition for immediate and extended release | FERRING BV | 2015-07-22 | — | — | CN | disclosed |
| CN-104606128-A | A FAST DISSOLVING PHARMACEUTICAL COMPOSITION | FERRING BV | 2015-05-13 | — | — | CN | disclosed |
| CN-102834091-B | Fast dissolving pharmaceutical composition | FERRING BV | 2015-04-22 | — | — | CN | disclosed |
| US-20150045764-A1 | SILK RESERVOIRS FOR DRUG DELIVERY | TRUSTEES OF TUFTS COLLEGE | 2015-02-12 | — | — | US | disclosed |
| EP-2827884-A1 | SILK RESERVOIRS FOR DRUG DELIVERY | Trustees Of Tufts College (US) | 2015-01-28 | — | — | EP | disclosed |
| CN-103945834-A | Biocompatible film with variable cross-sectional properties | MONOSOL RX LLC | 2014-07-23 | — | — | CN | disclosed |
| CN-103781467-A | Fast dissolving pharmaceutical composition | FERRING BV | 2014-05-07 | — | — | CN | disclosed |
| WO-2013148158-A1 | LASER-ACTUATED THERAPEUTIC NANOPARTICLES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-10-03 | — | — | WO | disclosed |
| WO-2013142119-A1 | SILK RESERVOIRS FOR DRUG DELIVERY | TRUSTEES OF TUFTS COLLEGE (US) | 2013-09-26 | — | — | WO | disclosed |
| CN-102834091-A | Fast dissolving pharmaceutical composition | FERRING BV | 2012-12-19 | — | — | CN | disclosed |
| CN-102821755-A | Fast dissolving pharmaceutical composition | FERRING BV | 2012-12-12 | — | — | CN | disclosed |
| US-20110240504-A1 | METHOD AND APPARATUS FOR PACKAGING AND DISPENSING PHARMACEUTICALS | APOTEX TECHNOLOGIES INC. (CA) | 2011-10-06 | — | — | US | disclosed |
| CN-101878025-A | Extrudable and extruded compositions for delivery of bioactive agents, methods of making and methods of using the same | FUISZ RICHARD C | 2010-11-03 | — | — | CN | disclosed |
| CN-101610670-A | The preparation and the purposes of 2-hydroxyl-5-phenylazobenzoic acid derivatives | SALIX PHARMACEUTICALS INC (US) | 2009-12-23 | — | — | CN | disclosed |