Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenoxylate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 5/20 | 0.64 |
| ▸ | KCNA3 | P22001 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenoxylate SCHEMBL16766515 | 0.99 | OPRM1 (0.65) | OPRM1KCNA3ALDH1A1MAPTCHRM2 | |
| Diphenoxylate SCHEMBL4060051 | 0.97 | OPRM1 (0.69) | OPRM1KCNA3ALDH1A1MAPTCHRM2 | |
| Diphenoxylate SCHEMBL2522739 | 0.97 | OPRM1 (0.69) | OPRM1KCNA3ALDH1A1MAPTCHRM2 | |
| Atropine SCHEMBL27893159 | 0.86 | MAPT (0.69) | OPRM1KCNA3ALDH1A1MAPTCHRM2 | |
| Atropine SCHEMBL27778826 | 0.86 | MAPT (0.69) | OPRM1KCNA3ALDH1A1MAPTCHRM2 | |
| Diphenoxylate SCHEMBL1831278 | 0.83 | OPRM1 (0.51) | OPRM1KCNA3ALDH1A1CHRM2CHRM5 | |
| Atropine SCHEMBL27778824 | 0.82 | MAPT (0.63) | OPRM1KCNA3ALDH1A1MAPTCHRM2 | |
| Atropine SCHEMBL27893156 | 0.81 | MAPT (0.61) | OPRM1KCNA3ALDH1A1MAPTCHRM2 | |
| Diphenoxylate SCHEMBL42124 | 0.81 | OPRM1 (0.98) | OPRM1KCNA3ADRA1ASLC22A1OPRD1 | |
| Diphenoxylate SCHEMBL42940 | 0.80 | OPRM1 (1.00) | OPRM1KCNA3ADRA1ASLC22A1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 301 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4638457-A1 | HETEROCYCLES AND USES THEREOF | Kumquat Biosciences Inc. (US) | 2025-10-29 | — | — | EP | claimed |
| EP-4333999-B1 | A GOLF GLOVE | OBRIEN CONOR (IE) | 2025-09-24 | — | — | EP | claimed |
| EP-4608305-A1 | APPLICATOR FOR APPLYING PASTY TRANSPLANTS IN SURGERY, AND APPLICATOR SET WITH ASSOCIATED INSTRUMENTS | REINHARD Feinmechanik GmbH (DE) | 2025-09-03 | — | — | EP | claimed |
| WO-2024264070-A2 | AKT INHIBITORS | Stablix, Inc. (US) | 2024-12-26 | — | — | WO | claimed |
| WO-2024138052-A1 | HETEROCYCLES AND USES THEREOF | KUMQUAT BIOSCIENCES INC. (US) | 2024-06-27 | — | — | WO | claimed |
| WO-2024088903-A1 | APPLICATOR FOR APPLYING PASTY TRANSPLANTS IN SURGERY, AND APPLICATOR SET WITH ASSOCIATED INSTRUMENTS | REINHARD FEINMECHANIK GMBH (DE) | 2024-05-02 | — | — | WO | claimed |
| EP-4269394-A1 | BENZOTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT | Korea Research Institute of Chemical Technology (KR) | 2023-11-01 | — | — | EP | claimed |
| EP-3108558-B1 | DISPLAY DEVICE FOR CALCULATION AND DISPLAY OF ARC FLASH INCIDENT ENERGY | EATON INTELLIGENT POWER LTD (IE) | 2023-05-31 | — | — | EP | claimed |
| EP-4172144-A2 | PROCESSES FOR MAKING SERD TRICYCLIC COMPOUNDS HAVING A SUBSTITUTED PHENYL OR PYRIDINYL MOIETY | Genentech, Inc. (US) | 2023-05-03 | — | — | EP | claimed |
| US-20220357476-A1 | INVERSION METHOD AND APPARATUS FOR MULTILAYER SEABED GEOACOUSTIC PARAMETER IN SHALLOW SEA, COMPUTER DEVICE AND STORAGE MEDIUM | ZHEJIANG OCEAN UNIVERSITY (CN) | 2022-11-10 | — | — | US | claimed |
| WO-2022159745-A1 | GCN2 MODULATING COMPOUNDS AND USES THEREOF | HIBERCELL, INC. (US) | 2022-07-28 | — | — | WO | claimed |
| EP-4003966-A1 | 5-AMINO SUBSTITUTED PYRAZOLES AND TRIAZOLES AS PEST CONTROL AGENTS | Bayer Aktiengesellschaft (DE) | 2022-06-01 | — | — | EP | claimed |
| EP-3042645-B1 | Dental composites with improved storage stability | IVOCLAR VIVADENT AG (LI) | 2022-04-27 | — | — | EP | claimed |
| US-12629319-B2 | Injection apparatus and method of use | MOBIUS THERAPEUTICS, INC. (US) | 2026-05-19 | — | — | US | disclosed |
| EP-4082552-B1 | LIQUIDS RICH IN NOBLE GAS AND METHODS OF THEIR PREPARATION AND USE | UNIV TEXAS (US) | 2026-05-06 | — | — | EP | disclosed |
| US-12581211-B2 | Imaging circuit and imaging device | SONY SEMICONDUCTOR SOLUTIONS CORPORATION (JP) | 2026-03-17 | — | — | US | disclosed |
| EP-0852503-A4 | COMPOSITION FOR THE TREATMENT OF DIARRHEA, ITS USE AND ITS PREPARATION | ABU SHAABAN MEDHAT (US) | 1999-02-10 | — | — | EP | disclosed |
| EP-0852503-A1 | COMPOSITION FOR THE TREATMENT OF DIARRHEA, ITS USE AND ITS PREPARATION | Abu-Shaaban, Medhat (US) | 1998-07-15 | — | — | EP | disclosed |
| US-5576001-A | Composition for the treatment of diarrhea, its use and its preparation | ABU-SHAABAN MEDHAT (US) | 1996-11-19 | — | — | US | disclosed |
| WO-1996025940-A1 | COMPOSITION FOR THE TREATMENT OF DIARRHEA, ITS USE AND ITS PREPARATION | ABU SHAABAN MEDHAT (US) | 1996-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12581211-B2 | Imaging circuit and imaging device | TMCO1, NCS1, HCN4 | OPRM1 4128/4885KCNA3 895/4885ALDH1A1 2944/4885 |
| US-12629319-B2 | Injection apparatus and method of use | IL6, TNF, IL2 | OPRM1 4264/4885KCNA3 784/4885ALDH1A1 4114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.