Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.56 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.49 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DDO | Q99489 | 1/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.43 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CTSA | P10619 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28238707 | 0.84 | CTSA (0.53) | HCAR2MKNK1MKNK2TBXA2RPTGER1 | |
| SCHEMBL1840398 | 0.81 | MKNK1 (0.68) | HCAR2MKNK1MKNK2SCN2ASCN10A | |
| SCHEMBL3072205 | 0.81 | ALPL (0.57) | HCAR2MKNK1MKNK2TBXA2RPTGER1 | |
| SCHEMBL2050887 | 0.80 | SRD5A2 (0.68) | PTGER1ALDH1A1TP53SRD5A2KDM4E | |
| SCHEMBL29788156 | 0.80 | SRD5A2 (0.68) | PTGER1ALDH1A1TP53SRD5A2KDM4E | |
| SCHEMBL30775592 | 0.79 | MKNK1 (0.59) | HCAR2MKNK1MKNK2SRD5A2KDM4E | |
| SCHEMBL25234831 | 0.79 | CYP2C9 (0.54) | ALDH1A1POLBKDM4ELMNACTSA | |
| SCHEMBL4401794 | 0.77 | RXRA (0.58) | HCAR2MKNK1MKNK2MAP4K4 | |
| SCHEMBL3181717 | 0.76 | MKNK1 (0.69) | HCAR2MKNK1MKNK2ALDH1A1POLB | |
| SCHEMBL14691606 | 0.76 | KMO (0.49) | HCAR2MKNK1MKNK2CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023114977-A1 | S1PR4 RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF | TIAKI THERAPEUTICS, INC. (US) | 2023-06-22 | — | — | WO | disclosed |