Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 12/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25243614 | 0.85 | TYK2 (0.52) | TYK2POLBGAATNNI3KAKR1C3 | |
| SCHEMBL25285692 | 0.78 | TYK2 (0.59) | TYK2POLBGAATNNI3KJAK1 | |
| SCHEMBL25249691 | 0.77 | TYK2 (0.42) | TYK2POLBGAA | |
| SCHEMBL25289232 | 0.76 | TYK2 (0.61) | TYK2 | |
| SCHEMBL25288885 | 0.75 | POLB (0.48) | TYK2POLBGAATNNI3KAKR1C3 | |
| SCHEMBL25243670 | 0.75 | POLB (0.48) | TYK2POLBGAATNNI3KAKR1C3 | |
| SCHEMBL25242779 | 0.75 | POLB (0.48) | TYK2POLBGAATNNI3KAKR1C3 | |
| SCHEMBL25243819 | 0.75 | TYK2 (0.66) | TYK2POLBGAATNNI3KAKR1C3 | |
| SCHEMBL25289262 | 0.74 | TYK2 (0.47) | TYK2POLBGAATNNI3KAKR1C3 | |
| SCHEMBL25289237 | 0.73 | GAA (0.39) | TYK2POLBGAATNNI3KAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | claimed |
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | disclosed |