Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A1 | Q06495 | 14/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25283606 | 0.89 | TYK2 (0.34) | SLC34A1PIK3C3JAK1TYK2 | |
| SCHEMBL25241283 | 0.87 | PIK3C3 (0.34) | PIK3C3TYK2 | |
| SCHEMBL25288932 | 0.87 | TYK2 (0.38) | PIK3C3JAK2JAK1TYK2KCNH2 | |
| SCHEMBL25249994 | 0.86 | TYK2 (0.40) | SLC34A1MAPK10JAK2JAK1TYK2 | |
| SCHEMBL25242170 | 0.83 | TYK2 (0.39) | PIK3C3TYK2 | |
| SCHEMBL25290634 | 0.80 | TYK2 (0.43) | PIK3C3TYK2 | |
| SCHEMBL25284264 | 0.79 | MAP4K1 (0.47) | PIK3C3TYK2 | |
| SCHEMBL25240241 | 0.78 | TYK2 (0.34) | PIK3C3TYK2 | |
| SCHEMBL25286994 | 0.73 | TYK2 (0.31) | PIK3C3TYK2 | |
| SCHEMBL25284327 | 0.72 | TYK2 (0.43) | TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | claimed |
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | disclosed |