Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 14/20 | 0.40 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | JAK1 | P23458 | 3/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | SLC34A1 | Q06495 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25243202 | 0.86 | SLC34A1 (0.35) | TYK2JAK2JAK1JAK3KIT | |
| SCHEMBL25241788 | 0.82 | TYK2 (0.39) | TYK2 | |
| SCHEMBL25282395 | 0.79 | TYK2 (0.53) | TYK2JAK2JAK1KIT | |
| SCHEMBL25283606 | 0.75 | TYK2 (0.34) | TYK2JAK1SLC34A1 | |
| SCHEMBL25244416 | 0.74 | TYK2 (0.39) | TYK2 | |
| SCHEMBL25288932 | 0.73 | TYK2 (0.38) | TYK2JAK2JAK1KCNH2 | |
| SCHEMBL25241283 | 0.72 | PIK3C3 (0.34) | TYK2 | |
| SCHEMBL25282339 | 0.71 | PIK3C3 (0.40) | TYK2 | |
| SCHEMBL25241375 | 0.70 | TYK2 (0.49) | TYK2 | |
| SCHEMBL25287069 | 0.70 | BACE1 (0.37) | TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | claimed |
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | disclosed |