Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.34 |
| ▸ | TDO2 | P48775 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 2/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1899980 | 0.73 | PGR (0.40) | IDO1TDO2MAOBKMT2AMEN1 | |
| SCHEMBL562407 | 0.71 | CYP1A2 (0.56) | CYP2C9HSD17B10ESR1ESR2KMT2A | |
| SCHEMBL2878152 | 0.70 | EGFR (0.44) | IDO1TDO2HSD17B10ALDH1A1MAPT | |
| SCHEMBL27986400 | 0.70 | PGR (0.45) | MAOBCYP2C9HSD17B10ESR1ESR2 | |
| SCHEMBL10562450 | 0.66 | MAOB (0.50) | IDO1MAOBESR1ESR2MAPT | |
| SCHEMBL2887312 | 0.66 | CDYL2 (0.42) | IDO1TDO2HSD17B10MAPTKMT2A | |
| SCHEMBL1400719 | 0.66 | ESR1 (0.61) | ESR1ESR2 | |
| SCHEMBL820847 | 0.66 | ESR1 (0.61) | ESR1ESR2 | |
| SCHEMBL5789865 | 0.66 | ESR1 (0.61) | ESR1ESR2 | |
| SCHEMBL820547 | 0.66 | ESR1 (0.61) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039484-B2 | Antidiabetic bicyclic compounds | MERCK SHARP & DOHME CORP. (US) | 2011-10-18 | — | — | US | disclosed |