Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1299584 | 0.75 | NISCH (0.44) | CA2ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL1299583 | 0.75 | NISCH (0.44) | CA2ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL1299611 | 0.75 | NISCH (0.44) | CA2ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL28731924 | 0.73 | CA2 (0.39) | CA2ADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL7437647 | 0.73 | CA2 (0.44) | CA2FFAR1ALDH1A1KMT2AAHR | |
| SCHEMBL6982180 | 0.71 | CA2 (0.59) | CA2ADRA1DADRA1AADRA1BFFAR1 | |
| SCHEMBL6982176 | 0.71 | CA2 (0.59) | CA2ADRA1DADRA1AADRA1BFFAR1 | |
| SCHEMBL7446435 | 0.71 | AHR (0.37) | AHR | |
| SCHEMBL7434309 | 0.69 | CA2 (0.48) | CA2ADRA1DADRA1AADRA1BFFAR1 | |
| SCHEMBL2487394 | 0.69 | CA2 (0.48) | CA2FFAR1AHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364303-A1 | ARYL PIPERAZINE AND THEIR USE AS ALPHA2C ANTAGONISTS | Orion Corporation (FI) | 2011-09-14 | — | — | EP | disclosed |
| WO-2010058060-A1 | ARYL PIPERAZINE AND THEIR USE AS ALPHA2C ANTAGONISTS | ORION CORPORATION (FI) | 2010-05-27 | — | — | WO | disclosed |