Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 5/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.44 |
| ▸ | CSNK1E | P49674 | 13/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 12/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16708797 | 0.96 | CSNK1D (0.42) | THRBTGFBR1CSNK1ECSNK1DCHRNB4 | |
| SCHEMBL2527781 | 0.83 | THRB (0.43) | THRBTGFBR1CSNK1ECSNK1D | |
| SCHEMBL2522830 | 0.82 | THRB (0.53) | THRBTGFBR1CSNK1ECSNK1D | |
| SCHEMBL2521875 | 0.82 | THRB (0.43) | THRBTGFBR1 | |
| SCHEMBL2522571 | 0.78 | THRB (0.49) | THRBTGFBR1CSNK1ECSNK1D | |
| SCHEMBL2524316 | 0.78 | PTGS2 (0.45) | THRBTGFBR1 | |
| SCHEMBL2522902 | 0.77 | THRB (0.48) | THRBTGFBR1CSNK1ECSNK1D | |
| SCHEMBL16709096 | 0.76 | CHRNB4 (0.36) | CSNK1ECSNK1DCHRNB4CHRNA3 | |
| SCHEMBL16699295 | 0.76 | CSNK1E (0.56) | CSNK1ECSNK1D | |
| SCHEMBL16708796 | 0.75 | CSNK1E (0.62) | CSNK1ECSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102947303-B | Bicyclo-pyridyl pyrazoles | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-12-14 | — | — | CN | disclosed |
| EP-2556073-B1 | BICYCLIC PYRIDINYL PYRAZOLES | BAYER IP GMBH (DE) | 2014-07-23 | — | — | EP | disclosed |
| US-8507472-B2 | Bicyclic pyridinylpyrazoles | BAYER CROPSCIENCE AG (DE) | 2013-08-13 | — | — | US | disclosed |
| CN-102947303-A | Bicyclic pyrimidinyl pyrazoles | BAYER CROPSCIENCE AG | 2013-02-27 | — | — | CN | disclosed |
| EP-2556073-A1 | BICYCLIC PYRIMIDINYL PYRAZOLES | Bayer Intellectual Property GmbH (DE) | 2013-02-13 | — | — | EP | disclosed |
| WO-2011124539-A1 | BICYCLIC PYRIMIDINYL PYRAZOLES | BAYER CROPSCIENCE AG (DE) | 2011-10-13 | — | — | WO | disclosed |
| US-20110251178-A1 | Bicyclic Pyridinylpyrazoles | BAYER CROPSCIENCE AG (DE) | 2011-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251178-A1 | Bicyclic Pyridinylpyrazoles | PLPBP, PNPO, PIR | THRB 3803/4885TGFBR1 2921/4885CSNK1E 3979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.