Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25260977 | 0.95 | PDE4B (0.46) | TLR9TLR8TLR7MEN1KMT2A | |
| SCHEMBL30484134 | 0.95 | TLR9 (0.44) | TLR9TLR8TLR7DDB1CRBN | |
| SCHEMBL25296825 | 0.93 | TLR9 (0.45) | TLR9TLR8TLR7DDB1CRBN | |
| SCHEMBL30484120 | 0.89 | PDE4B (0.47) | TLR9TLR8TLR7PIK3CDHPGDS | |
| SCHEMBL25831135 | 0.89 | PDE4B (0.47) | TLR9TLR8TLR7PIK3CDHPGDS | |
| SCHEMBL25830816 | 0.87 | TLR9 (0.46) | TLR9TLR8TLR7DDB1CRBN | |
| SCHEMBL31017625 | 0.87 | TLR9 (0.46) | TLR9TLR8TLR7DDB1CRBN | |
| SCHEMBL25427387 | 0.86 | DDB1 (0.41) | DDB1CRBNMEN1KMT2AUSP2 | |
| SCHEMBL25831704 | 0.80 | DDB1 (0.42) | TLR9TLR8TLR7DDB1CRBN | |
| SCHEMBL25427872 | 0.78 | BTK (0.35) | NAMPTPIK3CDCNR1EGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023125907-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2023-07-06 | — | — | WO | disclosed |