Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.34 |
| ▸ | KIT | P10721 | 5/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30484104 | 0.95 | NAMPT (0.35) | NAMPTMKNK1KITTBK1SRC | |
| SCHEMBL25831080 | 0.95 | NAMPT (0.35) | NAMPTMKNK1KITTBK1SRC | |
| SCHEMBL30484047 | 0.79 | TBK1 (0.41) | NAMPTMKNK1KITTBK1CNR1 | |
| SCHEMBL25831072 | 0.79 | TBK1 (0.41) | NAMPTMKNK1KITTBK1CNR1 | |
| SCHEMBL25250155 | 0.78 | TLR9 (0.43) | NAMPTSRCEGFRPIK3CDCNR1 | |
| SCHEMBL25260977 | 0.77 | PDE4B (0.46) | SRCEGFRPIK3CD | |
| SCHEMBL25296825 | 0.73 | TLR9 (0.45) | NAMPTSRCEGFRPIK3CDCNR1 | |
| SCHEMBL22608963 | 0.72 | NAMPT (0.43) | NAMPTTBK1GRM5GRM1PDK4 | |
| SCHEMBL30484134 | 0.72 | TLR9 (0.44) | NAMPTPOLBPIK3CDCNR1 | |
| SCHEMBL30545737 | 0.71 | GRM5 (0.43) | NAMPTTBK1POLBGRM5GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023125907-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2023-07-06 | — | — | WO | disclosed |