Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25830816 | 1.00 | TLR9 (0.46) | TLR9TLR8TLR7DDB1CRBN | |
| SCHEMBL25296825 | 0.95 | TLR9 (0.45) | TLR9TLR8TLR7DDB1CRBN | |
| SCHEMBL30484134 | 0.93 | TLR9 (0.44) | TLR9TLR8TLR7DDB1CRBN | |
| SCHEMBL25831135 | 0.87 | PDE4B (0.47) | TLR9TLR8TLR7PDE4BMAPT | |
| SCHEMBL30484120 | 0.87 | PDE4B (0.47) | TLR9TLR8TLR7PDE4BMAPT | |
| SCHEMBL25250155 | 0.87 | TLR9 (0.43) | TLR9TLR8TLR7DDB1CRBN | |
| SCHEMBL25831704 | 0.83 | DDB1 (0.42) | TLR9TLR8TLR7DDB1CRBN | |
| SCHEMBL25260977 | 0.82 | PDE4B (0.46) | TLR9TLR8TLR7PDE4BMAPT | |
| SCHEMBL25427387 | 0.78 | DDB1 (0.41) | DDB1CRBNGPR119KDM4EMAPT | |
| SCHEMBL30127280 | 0.76 | PDE4B (0.52) | TLR9TLR8TLR7DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118414336-A | Degradation of Bruton Tyrosine Kinase (BTK) by conjugation of BTK inhibitors to E3 ligase ligands and methods of use | 百济神州有限公司 | 2024-07-30 | — | — | CN | disclosed |