Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SPR | P35270 | 2/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | SCD5 | Q86SK9 | 4/20 | 0.38 |
| ▸ | SCD | O00767 | 3/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25261953 | 0.81 | HTT (0.43) | KDM4EGLAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL162009 | 0.81 | NAPRT (0.43) | KDM4EGLAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL159379 | 0.81 | GABRP (0.43) | KDM4EGLAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL30395072 | 0.79 | DDB1 (0.46) | KDM4ESPR | |
| SCHEMBL20757383 | 0.79 | DDB1 (0.46) | KDM4ESPR | |
| SCHEMBL20743069 | 0.78 | KDM1A (0.40) | KMT2AKDM1AMAOAMAOB | |
| SCHEMBL25257655 | 0.77 | SMN1; SMN2 (0.40) | KDM4EGLAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL23211825 | 0.77 | SLC6A2 (0.43) | KDM4EGLAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL25255898 | 0.76 | SCD5 (0.38) | KDM4EGLAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL15513886 | 0.74 | SLC18A3 (0.42) | SMN1; SMN2SCD5SCDNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11981661-B2 | Heterocyclic compounds | HOFFMANN-LA ROCHE INC. (US) | 2024-05-14 | — | — | US | disclosed |
| EP-4208456-A1 | HETEROCYCLIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2023-07-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11981661-B2 | Heterocyclic compounds | CBR3, BRIX1, CCNY | KDM4E 1570/4885GLA 547/4885HTT 1702/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.