Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | LIPE | Q05469 | 3/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | SPR | P35270 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | USP9X | Q93008 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25292328 | 0.87 | CHRM1 (0.46) | CHRM1LIPEAKR1C3SPRKDM2B | |
| SCHEMBL25253193 | 0.81 | LIPE (0.44) | CHRM1LIPEAKR1C3SPRKDM2B | |
| SCHEMBL30409361 | 0.80 | MGLL (0.43) | CHRM1LIPEAKR1C3SPRKDM2B | |
| SCHEMBL30409535 | 0.79 | CHRM1 (0.40) | CHRM1LIPEAKR1C3SPRRORC | |
| SCHEMBL25251545 | 0.78 | MEN1 (0.48) | LIPEAKR1C3EPHX2MEN1KMT2A | |
| SCHEMBL25322792 | 0.77 | AKR1C3 (0.42) | CHRM1LIPEAKR1C3SPRKDM2B | |
| SCHEMBL25255840 | 0.76 | SCN9A (0.46) | LIPEAKR1C3KDM2BRORCEPHX2 | |
| SCHEMBL18711904 | 0.75 | CHRM1 (0.54) | CHRM1LIPEAKR1C3SPRKDM2B | |
| SCHEMBL11888909 | 0.75 | LIPE (0.50) | CHRM1LIPEAKR1C3SPRKDM2B | |
| SCHEMBL24754403 | 0.74 | CHRM1 (0.53) | CHRM1LIPEAKR1C3MMP2MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11981661-B2 | Heterocyclic compounds | HOFFMANN-LA ROCHE INC. (US) | 2024-05-14 | — | — | US | disclosed |
| EP-4208456-A1 | HETEROCYCLIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2023-07-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11981661-B2 | Heterocyclic compounds | CBR3, BRIX1, CCNY | CHRM1 758/4885LIPE 2733/4885AKR1C3 159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.