Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 1/20 | 0.43 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.43 |
| ▸ | ROS1 | P08922 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12745929 | 0.80 | RET (0.55) | CDK5ACVR1LRRK2ALDH1A1KDM4E | |
| SCHEMBL28928126 | 0.77 | ROS1 (0.40) | ROS1CDK5ACVR1LRRK2ALDH1A1 | |
| SCHEMBL23952183 | 0.75 | ROS1 (0.38) | ROS1CDK5ACVR1LRRK2ALDH1A1 | |
| SCHEMBL23952185 | 0.73 | THRB (0.34) | ALDH1A1KDM4EHSD17B10FFAR1 | |
| SCHEMBL23951911 | 0.69 | PDE4A (0.54) | PDE7APDE7BALDH1A1KDM4ECA12 | |
| SCHEMBL30110698 | 0.69 | PDE4A (0.54) | PDE7APDE7BALDH1A1KDM4ECA12 | |
| SCHEMBL12745931 | 0.69 | RET (0.55) | CDK5ACVR1LRRK2ALDH1A1KDM4E | |
| SCHEMBL12746150 | 0.69 | VEGFA (0.40) | ALKBH3TNKS2FFAR1PGRNPC1 | |
| SCHEMBL23951943 | 0.68 | TNKS2 (0.41) | LRRK2ALDH1A1KDM4ETNKS2NPC1 | |
| SCHEMBL19323001 | 0.68 | HPGD (0.45) | ALDH1A1KDM4EHSD17B10ALKBH3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219913-A1 | Sulfamoylamide Derivatives | HOFFMANN-LA ROCHE INC. (US) | 2023-07-13 | — | — | US | claimed |
| CN-115427402-A | Sulfamide derivatives | 豪夫迈·罗氏有限公司 | 2022-12-02 | — | — | CN | claimed |
| US-20230219913-A1 | Sulfamoylamide Derivatives | HOFFMANN-LA ROCHE INC. (US) | 2023-07-13 | — | — | US | disclosed |
| US-20230219913-A1 | Sulfamoylamide Derivatives | HOFFMANN-LA ROCHE INC. (US) | 2023-07-13 | — | — | US | disclosed |
| EP-4136081-A1 | SULFAMOYLAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2023-02-22 | — | — | EP | disclosed |
| CN-115427402-A | Sulfamide derivatives | 豪夫迈·罗氏有限公司 | 2022-12-02 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219913-A1 | Sulfamoylamide Derivatives | SULT2A1, SULT1A1, SPTLC3 | PDE7A 4591/4885PDE7B 4352/4885ROS1 3952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.