Sugi Predict

Sugi Predict / Compounds / SCHEMBL2525484

SCHEMBL2525484

SCHEMBL2525484

O=C(Cl)Cc1c(Cl)cccc1Cl

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ AKR1B1 P15121 1/20 0.68
▸ KMT2A Q03164 6/20 0.55
▸ ADRA2A P08913 2/20 0.55
▸ MEN1 O00255 2/20 0.55
▸ LMNA P02545 1/20 0.55
▸ CYP3A4 P08684 1/20 0.55
▸ HTR1A P08908 1/20 0.55
▸ CYP2D6 P10635 1/20 0.55
▸ CYP2C9 P11712 1/20 0.55
▸ ADRA2B P18089 1/20 0.55
▸ ADRA2C P18825 1/20 0.55
▸ MAOA P21397 1/20 0.55
▸ ADRA1D P25100 1/20 0.55
▸ HTR2A P28223 1/20 0.55
▸ HTR2C P28335 1/20 0.55
▸ MAPK1 P28482 1/20 0.55
▸ CYP2C19 P33261 1/20 0.55
▸ ADRA1A P35348 1/20 0.55
▸ DRD3 P35462 1/20 0.55
▸ OPRK1 P41145 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10423282 0.87 AKR1B1 (0.53) AKR1B1KMT2AADRA2AMEN1LMNA
SCHEMBL1885453 0.86 MAPT (0.59) AKR1B1KMT2AMEN1MAPTALDH1A1
SCHEMBL7674948 0.86 AKR1B1 (0.52) AKR1B1KMT2AADRA2AMEN1LMNA
SCHEMBL6475041 0.81 AKR1B1 (0.47) AKR1B1KMT2AADRA2AMEN1LMNA
SCHEMBL109215 0.81 AKR1B1 (1.00) AKR1B1KMT2AADRA2AMEN1LMNA
SCHEMBL11243678 0.81 AKR1B1 (0.68) AKR1B1KMT2AADRA2AMEN1LMNA
SCHEMBL9450310 0.80 AKR1B1 (0.50) AKR1B1KMT2AMEN1LMNACYP3A4
SCHEMBL4685080 0.79 AKR1B1 (0.65) AKR1B1KMT2AADRA2AMEN1LMNA
SCHEMBL11832033 0.79 AKR1B1 (0.43) AKR1B1KMT2AADRA2AMEN1LMNA
Hydrochloric Acid SCHEMBL1374156 0.79 AKR1B1 (0.95) AKR1B1KMT2AADRA2AMEN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103058890-A Method for preparing guanfacine hydrochloride ZHENGZHOU DAMING PHARMACEUTICAL TECHNOLOGY CO LTD 2013-04-24 — — CN claimed
US-20260137703-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER CANCER RESEARCH TECH LIMITED (GB) 2026-05-21 — — US disclosed
EP-4612148-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER Cancer Research Technology Limited (GB) 2025-09-10 — — EP disclosed
WO-2024094963-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2024-05-10 — — WO disclosed
CN-117024298-A Tertiary amide compound containing naphthyl and its preparation method and application 北京中医药大学 2023-11-10 — — CN disclosed
CN-108409684-B N- (2-cyclohexyloxyphenyl) amide compound and preparation method and application thereof 上海晓明检测技术服务有限公司 2022-04-12 — — CN disclosed
CN-108409684-A A kind of N- (2- cyclohexyloxies phenyl) amides compound and its preparation method and application 上海泰禾国际贸易有限公司 2018-08-17 — — CN disclosed
US-20160376291-A1 IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 JANSSEN PHARMACEUTICA NV (BE) 2016-12-29 — — US disclosed
US-9440978-B2 Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 JANSSEN PHARMACEUTICA NV (BE) 2016-09-13 — — US disclosed
CN-105732513-A Herbicidal and insecticidal phenyl-substituted pyridazinones 拜耳知识产权有限责任公司 2016-07-06 — — CN disclosed
EP-0116639-A1 ACYL GUANIDINES RORER INTERNATIONAL (OVERSEAS) INC. (US) 1984-08-29 — — EP disclosed
WO-1984000875-A1 ACYL GUANIDINES RORER INT OVERSEAS (US) 1984-03-15 — — WO disclosed
EP-0048045-A1 Phenyl piperazine derivatives having antiagressive activity DUPHAR INTERNATIONAL RESEARCH B.V (NL) 1982-03-24 — — EP disclosed
US-4318915-A Substituted guandines and methods of preparation thereof BEIERSDORF AKTIENGESELLSCHAFT (DE) 1982-03-09 — — US disclosed
US-4261994-A HYPOTENSIVE AGENTS SYNTHELABO (FR) 1981-04-14 — — US disclosed
US-4073936-A Hypolipidemic allene carboxylic esters SANDOZ, INC. (US) 1978-02-14 — — US disclosed
US-4067726-A 3-Ureido phenylacetamide herbicides BAYER AKTIENGESELLSCHAFT (DT) 1978-01-10 — — US disclosed
US-4016263-A BACTERICIDES BOEHRINGER INGELHEIM GMBH (DT) 1977-04-05 — — US disclosed
US-4011339-A ANTIINFLAMMATORY AGENTS SANDOZ, INC. (US) 1977-03-08 — — US disclosed
US-3992396-A TRANQUILIZERS, HYPNOTICS SANDOZ, INC. (US) 1976-11-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260137703-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER EGFR, KRAS, O60361 AKR1B1 1140/4885KMT2A 3265/4885ADRA2A 2131/4885
US-20160376291-A1 IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 TRPV1, TRPA1, TRPV4 AKR1B1 3705/4885KMT2A 4460/4885ADRA2A 738/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.