Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | PKLR | P30613 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 8/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 8/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.45 |
| ▸ | STS | P08842 | 1/20 | 0.44 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25297738 | 0.88 | HDAC8 (0.47) | HDAC8KITPKLRDPP4DPP7 | |
| SCHEMBL29497073 | 0.88 | HDAC8 (0.47) | HDAC8KITPKLRDPP4DPP7 | |
| SCHEMBL25146288 | 0.83 | HDAC8 (0.43) | HDAC8KITPKLRDPP4DPP7 | |
| SCHEMBL30700579 | 0.83 | KIT (0.44) | HDAC8KITPKLRDPP4DPP7 | |
| SCHEMBL25145667 | 0.82 | KIT (0.49) | HDAC8KITSTSKAT6AAKR1C3 | |
| SCHEMBL25324806 | 0.82 | KIT (0.43) | HDAC8KITPKLRDPP4DPP7 | |
| SCHEMBL25146054 | 0.82 | MGLL (0.48) | HDAC8KITPKLRDPP4DPP7 | |
| SCHEMBL25254510 | 0.80 | HDAC8 (0.40) | HDAC8KITPKLRDPP4DPP7 | |
| SCHEMBL30700662 | 0.78 | KIT (0.41) | HDAC8KITPKLRDPP4DPP7 | |
| SCHEMBL30699969 | 0.78 | KIT (0.45) | HDAC8KITPKLRDPP4DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11981661-B2 | Heterocyclic compounds | HOFFMANN-LA ROCHE INC. (US) | 2024-05-14 | — | — | US | disclosed |
| EP-4208456-A1 | HETEROCYCLIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2023-07-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11981661-B2 | Heterocyclic compounds | CBR3, BRIX1, CCNY | HDAC8 2323/4885KIT 512/4885PKLR 566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.