Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 10/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 9/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | STS | P08842 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | PKLR | P30613 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30699969 | 0.87 | KIT (0.45) | KITHDAC8DPP4DPP7KCNH2 | |
| SCHEMBL25324806 | 0.82 | KIT (0.43) | KITHDAC8DPP4DPP7KCNH2 | |
| SCHEMBL30700579 | 0.82 | KIT (0.44) | KITHDAC8DPP4DPP7KCNH2 | |
| SCHEMBL25255089 | 0.78 | HDAC8 (0.48) | KITHDAC8DPP4DPP7KCNH2 | |
| SCHEMBL25146288 | 0.77 | HDAC8 (0.43) | KITHDAC8DPP4DPP7KCNH2 | |
| SCHEMBL25324840 | 0.76 | HDAC8 (0.43) | KITHDAC8DPP4DPP7KCNH2 | |
| SCHEMBL25146054 | 0.76 | MGLL (0.48) | KITHDAC8DPP4DPP7KCNH2 | |
| SCHEMBL29497073 | 0.75 | HDAC8 (0.47) | KITHDAC8DPP4DPP7KCNH2 | |
| SCHEMBL25297738 | 0.75 | HDAC8 (0.47) | KITHDAC8DPP4DPP7KCNH2 | |
| SCHEMBL30700477 | 0.74 | CCNK (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | disclosed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | disclosed |