Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 15/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30543101 | 1.00 | PNMT (0.54) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL25290515 | 1.00 | PNMT (0.54) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL21489595 | 0.75 | PNMT (0.53) | PNMTADRA2A | |
| SCHEMBL29652240 | 0.75 | PNMT (0.53) | PNMTADRA2A | |
| SCHEMBL16267716 | 0.75 | PNMT (0.53) | PNMTADRA2A | |
| SCHEMBL26889205 | 0.75 | EGLN1 (0.41) | PNMTADRA2A | |
| Hydrochloric Acid SCHEMBL25297543 | 0.74 | GRIA2 (0.40) | — | |
| Hydrochloric Acid SCHEMBL25297542 | 0.74 | GRIA2 (0.40) | — | |
| Hydrochloric Acid SCHEMBL30543105 | 0.74 | GRIA2 (0.40) | — | |
| SCHEMBL22944381 | 0.71 | PNMT (0.59) | PNMTADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12503442-B2 | Phenyl-3,4-dihydroisoquinolin-2(1h)-yl-ethan-1-one derivatives as dopamine d1receptor positive allosteric modulators | ELI LILLY AND COMPANY (US) | 2025-12-23 | — | — | US | disclosed |
| EP-4200280-B1 | PHENYL-3,4-DIHYDROISOQUINOLIN-2(1H)-YL-ETHAN-1-ONE DERIVATIVES AS DOPAMINE D1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | LILLY CO ELI (US) | 2024-02-21 | — | — | EP | disclosed |
| US-20230382869-A1 | Phenyl-3,4-dihydroisoquinolin-2(1h)-yl-ethan-1-one derivatives as dopamine d1receptor positive allosteric modulators | ELI LILLY AND COMPANY | 2023-11-30 | — | — | US | disclosed |
| US-20230382869-A1 | Phenyl-3,4-dihydroisoquinolin-2(1h)-yl-ethan-1-one derivatives as dopamine d1receptor positive allosteric modulators | ELI LILLY AND COMPANY | 2023-11-30 | — | — | US | disclosed |
| US-20230382869-A1 | Phenyl-3,4-dihydroisoquinolin-2(1h)-yl-ethan-1-one derivatives as dopamine d1receptor positive allosteric modulators | ELI LILLY AND COMPANY | 2023-11-30 | — | — | US | disclosed |
| CN-116601146-A | Phenyl-3, 4-dihydroisoquinolin-2 (1H) -yl-ethan-1-one derivatives as positive allosteric modulators of dopamine D1 receptor | 伊莱利利公司 | 2023-08-15 | — | — | CN | disclosed |
| EP-4200280-A1 | PHENYL-3,4-DIHYDROISOQUINOLIN-2(1H)-YL-ETHAN-1-ONE DERIVATIVES AS DOPAMINE D1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | ELI LILLY AND COMPANY (US) | 2023-06-28 | — | — | EP | disclosed |
| WO-2022076418-A1 | PHENYL-3,4-DIHYDROISOQUINOLIN-2(1H)-YL-ETHAN-1-ONE DERIVATIVES AS DOPAMINE D1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | ELI LILLY AND COMPANY (US) | 2022-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230382869-A1 | Phenyl-3,4-dihydroisoquinolin-2(1h)-yl-ethan-1-one derivatives as dopamine d1receptor positive allosteric modulators | HTR1D, ADRA1D, HTR1A | PNMT 173/4885ADRA2A 35/4885ADRA2B 66/4885 |
| US-12503442-B2 | Phenyl-3,4-dihydroisoquinolin-2(1h)-yl-ethan-1-one derivatives as dopamine d1receptor positive allosteric modulators | HTR1D, ADRA1D, HTR1A | PNMT 173/4885ADRA2A 35/4885ADRA2B 66/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.