Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 1.00 |
| ▸ | GLA | P06280 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2527037 | 1.00 | ALDH1A1 (1.00) | ALDH1A1GLATDP1PKMTP53 | |
| SCHEMBL29498775 | 1.00 | ALDH1A1 (1.00) | ALDH1A1GLATDP1PKMTP53 | |
| SCHEMBL179950 | 1.00 | ALDH1A1 (1.00) | ALDH1A1GLATDP1PKMTP53 | |
| SCHEMBL29424137 | 1.00 | ALDH1A1 (1.00) | ALDH1A1GLATDP1PKMTP53 | |
| Water SCHEMBL28245542 | 0.98 | ALDH1A1 (0.96) | ALDH1A1GLATDP1PKMTP53 | |
| Methane SCHEMBL28274836 | 0.98 | ALDH1A1 (0.96) | ALDH1A1GLATDP1PKMTP53 | |
| Propane SCHEMBL28104053 | 0.96 | ALDH1A1 (0.93) | ALDH1A1GLATDP1PKMTP53 | |
| SCHEMBL22653916 | 0.95 | ALDH1A1 (0.90) | ALDH1A1GLATDP1PKMTP53 | |
| Propylene Oxide SCHEMBL28819413 | 0.95 | ALDH1A1 (0.90) | ALDH1A1GLATDP1PKMTP53 | |
| SCHEMBL425554 | 0.92 | ALDH1A1 (0.84) | ALDH1A1GLATDP1PKMTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114854714-A | Kidney bean source epoxide hydrolase mutant, gene, vector, engineering bacterium, preparation method and application | 安徽工程大学 | 2022-08-05 | — | — | CN | disclosed |
| CN-107189970-B | Pseudomonas adynaudiana YC1612 for producing halohydrin dehalogenase and application and preparation method thereof | 盐城工学院 | 2020-03-06 | — | — | CN | disclosed |
| CN-107189970-A | A kind of cloudy city pseudomonad YC1612 and its application and preparation method for producing halide alcohol dehalogenase | 盐城工学院 | 2017-09-22 | — | — | CN | disclosed |
| US-8039503-B2 | Lapachone compounds and methods of use thereof | ARQULE, INC. (US) | 2011-10-18 | — | — | US | disclosed |
| US-20110105470-A1 | Novel Lapachone Compounds And Methods of Use Thereof | ARQULE, INC. (US) | 2011-05-05 | — | — | US | disclosed |
| US-7902354-B2 | Lapachone compounds and methods of use thereof | ARQULE, INC. (US) | 2011-03-08 | — | — | US | disclosed |
| US-20090105166-A1 | Novel lapachone compounds and methods of use thereof | ARQULE, INC. | 2009-04-23 | — | — | US | disclosed |
| EP-2035435-A1 | NOVEL LAPACHONE COMPOUNDS AND METHODS OF USE THEREOF | ARQULE, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007139569-A1 | NOVEL LAPACHONE COMPOUNDS AND METHODS OF USE THEREOF | ARQULE, INC. (US) | 2007-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105470-A1 | Novel Lapachone Compounds And Methods of Use Thereof | BAD, NQO1, CASP3 | ALDH1A1 906/4885GLA 606/4885TDP1 2203/4885 |
| US-20090105166-A1 | Novel lapachone compounds and methods of use thereof | BAD, NQO1, CASP3 | ALDH1A1 906/4885GLA 606/4885TDP1 2203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.