Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21870191 | 0.86 | MAPT (0.66) | MAPTTSHRSMN1; SMN2POLBMAPK1 | |
| SCHEMBL29989633 | 0.79 | MAPT (1.00) | MAPTTSHRSMN1; SMN2POLBMAPK1 | |
| SCHEMBL4651272 | 0.79 | MAPT (1.00) | MAPTTSHRSMN1; SMN2POLBMAPK1 | |
| SCHEMBL29158025 | 0.79 | SMN1; SMN2 (0.76) | MAPTTSHRSMN1; SMN2POLBMAPK1 | |
| SCHEMBL6178491 | 0.79 | MAPT (0.74) | MAPTTSHRSMN1; SMN2POLBMAPK1 | |
| SCHEMBL20515255 | 0.78 | GAA (0.73) | MAPTSMN1; SMN2POLBKDM4EALDH1A1 | |
| SCHEMBL25308546 | 0.75 | KMT2A (0.57) | MAPTTSHRMAPK1KDM4EALDH1A1 | |
| SCHEMBL32660990 | 0.75 | GAA (0.59) | SMN1; SMN2ALDH1A1LMNAHIF1A | |
| SCHEMBL10473593 | 0.75 | RAB9A (0.62) | TSHRSMN1; SMN2POLBKDM4EALDH1A1 | |
| SCHEMBL21870357 | 0.75 | HDAC3 (0.62) | MAPTSMN1; SMN2KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023134708-A1 | THIAZOLOPYRIDYL AMIDE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | BEIGENE , LTD. (KY) | 2023-07-20 | — | — | WO | disclosed |