Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 9/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 2/20 | 0.35 |
| ▸ | SLC34A1 | Q06495 | 7/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25242862 | 0.85 | TTK (0.41) | TYK2JAK1TTKSLC34A1POLB | |
| SCHEMBL25283616 | 0.83 | PIK3C3 (0.34) | TYK2POLBGAA | |
| SCHEMBL25292442 | 0.82 | TTK (0.41) | TYK2JAK1TTKLRRK2 | |
| SCHEMBL25286881 | 0.76 | TTK (0.57) | TTKLRRK2 | |
| SCHEMBL25289334 | 0.75 | MAPT (0.31) | TYK2JAK1TTK | |
| SCHEMBL25283690 | 0.75 | PIK3C3 (0.31) | TTK | |
| SCHEMBL25241788 | 0.75 | TYK2 (0.39) | TYK2 | |
| SCHEMBL25287069 | 0.74 | BACE1 (0.37) | TYK2 | |
| SCHEMBL25244450 | 0.73 | TTK (0.41) | TTKSLC34A1LRRK2 | |
| SCHEMBL25282403 | 0.72 | GRM5 (0.43) | TYK2JAK1POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | claimed |
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | disclosed |