Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 3/20 | 0.67 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.67 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.67 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.67 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.58 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.67 |
| ▸ | HRH1 | P35367 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.67 |
| ▸ | HTR2A | P28223 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | ESR1 | P03372 | 1/20 | 0.67 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.67 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.67 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.67 |
| ▸ | HRH2 | P25021 | 1/20 | 0.67 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.67 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2528597 | 1.00 | CHRM2 (0.67) | CHRM2CHRM1HRH1MAPTCHRM5 | |
| SCHEMBL614300 | 0.99 | CHRM2 (0.68) | CHRM2CHRM1HRH1MAPTCHRM5 | |
| SCHEMBL2522817 | 0.99 | CHRM2 (0.68) | CHRM2CHRM1HRH1MAPTCHRM5 | |
| Hydrochloric Acid SCHEMBL615546 | 0.97 | CHRM2 (0.67) | CHRM2CHRM1HRH1MAPTCHRM5 | |
| Fumaric Acid SCHEMBL1261697 | 0.90 | CHRM2 (0.61) | CHRM2CHRM1HRH1MAPTCHRM5 | |
| Fumaric Acid SCHEMBL1261695 | 0.90 | CHRM2 (0.61) | CHRM2CHRM1HRH1MAPTCHRM5 | |
| Cadaverine Tartrate SCHEMBL2528604 | 0.90 | CHRM2 (0.74) | CHRM2CHRM1HRH1MAPTCHRM5 | |
| Cadaverine Tartrate SCHEMBL2528602 | 0.90 | CHRM2 (0.74) | CHRM2CHRM1HRH1MAPTCHRM5 | |
| SCHEMBL9227827 | 0.90 | MAPT (0.55) | CHRM2CHRM1HRH1MAPTCHRM5 | |
| SCHEMBL9228278 | 0.89 | CHRM2 (0.53) | CHRM2CHRM1HRH1MAPTCHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039672-B2 | Method of obtaining 3,3-diphenylpropylamines | INTERQUIM, S.A. (ES) | 2011-10-18 | — | — | US | claimed |
| US-20100286446-A1 | Method of Obtaining 3,3-Diphenylpropylamines | INTERQUIM, S.A. (ES) | 2010-11-11 | — | — | US | claimed |
| US-7473805-B2 | Process for obtaining tolterodine | RAGACTIVES, S.L. PARQUE TECNOLOGICO DE BOECILLO (ES) | 2009-01-06 | — | — | US | claimed |
| EP-1927585-A2 | METHOD OF OBTAINING 3,3-DIPHENYLPROPYLAMINES | Ragactives, S.L. (ES) | 2008-06-04 | — | — | EP | claimed |
| US-20070254959-A1 | Process for Obtaining Tolterodine | RAGACTIVES, S.L. (ES) | 2007-11-01 | — | — | US | claimed |
| EP-1698615-B1 | METHOD OF OBTAINING TOLTERODINE | RAGACTIVES SL (ES) | 2007-10-31 | — | — | EP | claimed |
| EP-1698615-A1 | METHOD OF OBTAINING TOLTERODINE | Ragactives, S.L. (ES) | 2006-09-06 | — | — | EP | claimed |
| US-20110319666-A1 | METHOD OF OBTAINING 3,3-DIPHENYLPROPYLAMINES | BONDE-LARSEN ANTONIO LORENTE (ES) | 2011-12-29 | — | — | US | disclosed |
| US-8039672-B2 | Method of obtaining 3,3-diphenylpropylamines | INTERQUIM, S.A. (ES) | 2011-10-18 | — | — | US | disclosed |
| US-20100286446-A1 | Method of Obtaining 3,3-Diphenylpropylamines | INTERQUIM, S.A. (ES) | 2010-11-11 | — | — | US | disclosed |
| US-7473805-B2 | Process for obtaining tolterodine | RAGACTIVES, S.L. PARQUE TECNOLOGICO DE BOECILLO (ES) | 2009-01-06 | — | — | US | disclosed |
| EP-1927585-A2 | METHOD OF OBTAINING 3,3-DIPHENYLPROPYLAMINES | Ragactives, S.L. (ES) | 2008-06-04 | — | — | EP | disclosed |
| US-20070254959-A1 | Process for Obtaining Tolterodine | RAGACTIVES, S.L. (ES) | 2007-11-01 | — | — | US | disclosed |
| EP-1698615-B1 | METHOD OF OBTAINING TOLTERODINE | RAGACTIVES SL (ES) | 2007-10-31 | — | — | EP | disclosed |
| EP-1698615-A1 | METHOD OF OBTAINING TOLTERODINE | Ragactives, S.L. (ES) | 2006-09-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254959-A1 | Process for Obtaining Tolterodine | ADRB2, ADRB3, ADRB1 | CHRM2 19/4885CHRM3 14/4885SLC6A4 370/4885 |
| US-20110319666-A1 | METHOD OF OBTAINING 3,3-DIPHENYLPROPYLAMINES | CHRM3, CNR2, CHRM2 | CHRM2 3/4885CHRM3 1/4885SLC6A4 113/4885 |
| US-20100286446-A1 | Method of Obtaining 3,3-Diphenylpropylamines | CHRM3, HRH4, ADRB3 | CHRM2 4/4885CHRM3 1/4885SLC6A4 102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.