Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2527546 | 0.92 | TDP1 (0.47) | TDP1KDM4EGAASMN1; SMN2AOC3 | |
| SCHEMBL2527514 | 0.91 | PDGFRB (0.41) | TDP1KDM4EGAASMN1; SMN2AOC3 | |
| SCHEMBL2526965 | 0.87 | LMNA (0.47) | TDP1KDM4EGAASMN1; SMN2L3MBTL1 | |
| SCHEMBL2529623 | 0.86 | ADRB3 (0.45) | TDP1KDM4EGAASMN1; SMN2KMT2A | |
| SCHEMBL2528949 | 0.85 | L3MBTL1 (0.42) | TDP1KDM4EGAASMN1; SMN2L3MBTL1 | |
| SCHEMBL2527446 | 0.85 | PPARG (0.42) | TDP1KDM4EGAASMN1; SMN2KMT2A | |
| SCHEMBL2532004 | 0.85 | HSD17B10 (0.44) | TDP1KDM4EGAASMN1; SMN2AOC3 | |
| SCHEMBL2527801 | 0.85 | MEN1 (0.42) | TDP1KDM4EGAASMN1; SMN2AOC3 | |
| SCHEMBL2531906 | 0.84 | ADRB3 (0.38) | TDP1KDM4EGAASMN1; SMN2L3MBTL1 | |
| SCHEMBL2526478 | 0.84 | PPARG (0.38) | TDP1KDM4EGAASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039501-B2 | Synephrine derivatives useful as anti-inflammatory agents | UNIVERSITEIT GENT (BE) | 2011-10-18 | — | — | US | disclosed |
| US-20090029999-A1 | Synephrine derivatives useful as anti-inflammatory agents | UNIVERSITEIT GENT (BE) | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090029999-A1 | Synephrine derivatives useful as anti-inflammatory agents | HRH1, HRH3, HRH2 | TDP1 3871/4885KDM4E 3080/4885GAA 4431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.